HIV-1 protease — Drug Target

All drugs that target HIV-1 protease — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

Protease Inhibitors · HIV protease inhibitor · Protease inhibitor · protease inhibitor

Marketed (2)

• Riv · Pfizer · Protease Inhibitors · Infectious Disease
• Triple therapy with ritonavir · Sociedad Andaluza de Enfermedades Infecciosas · HIV protease inhibitor · Infectious Disease
  Ritonavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.

Phase 3 pipeline (7)

• continue the PI/r-containing HAART. · ASST Fatebenefratelli Sacco · Protease inhibitor · Infectious disease
  Ritonavir is a protease inhibitor used to treat HIV-1 infection by preventing the replication of the virus.
• LEXIVA (GW433908) · ViiV Healthcare · HIV protease inhibitor · Infectious Disease
  Lexiva is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
• LPV · Bristol-Myers Squibb · HIV protease inhibitor · Infectious Disease
  LPV is a protease inhibitor that blocks HIV protease, preventing the maturation of HIV virions and reducing viral replication.
• TMC435 · Tibotec Pharmaceuticals, Ireland · protease inhibitor · Infectious Diseases
  TMC435 is a protease inhibitor used to treat HIV-1 infection.
• lopinavir/ritonavir (LPV/r) · French National Agency for Research on AIDS and Viral Hepatitis · Protease inhibitor · Infectious disease
  Lopinavir/ritonavir is a protease inhibitor used to treat HIV-1 infection by preventing the replication of the virus.
• Tipranavir/Ritonavir · Johns Hopkins University · Protease inhibitor · Infectious disease
  Tipranavir/Ritonavir is a protease inhibitor used in combination with other medications to treat HIV-1 infection.
• TMC114 · Tibotec Pharmaceuticals, Ireland · protease inhibitor · Infectious Diseases
  TMC114 is a protease inhibitor used to treat HIV-1 infection.