What are HIV protease inhibitor drugs?

HIV protease inhibitor drugs are pharmacologic agents that share a common mechanism (typically targeting HIV protease). 22 are currently marketed, with 13 more in clinical development.

What are the marketed HIV protease inhibitor drugs?

Marketed HIV protease inhibitor drugs include Fosamprenavir/ritonavir, Saquinavir (Invirase®), saquinavir/ritonavir, Atazanavir ritonavir, Darunavir/r, Lopinavir and Ritonavir Tablets.

HIV protease inhibitor

22 marketed 12 in Phase 3 1 in Phase 2

This page covers all HIV protease inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting HIV protease, HIV-1 protease.

Targets

HIV protease · HIV-1 protease

Marketed (22)

Fosamprenavir/ritonavir · ViiV Healthcare · Infectious Disease
Fosamprenavir is a protease inhibitor that blocks HIV protease, preventing viral replication, while ritonavir acts as a pharmacokinetic booster to increase fosamprenavir levels.
Saquinavir (Invirase®) · Royal Free Hampstead NHS Trust · Infectious Disease
Saquinavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
saquinavir/ritonavir · International Antiviral Therapy Evaluation Center · Infectious Disease
Saquinavir and ritonavir are protease inhibitors that block HIV protease, preventing viral replication by inhibiting the cleavage of viral polyproteins.
Atazanavir ritonavir · Göteborg University · Infectious Disease
Atazanavir is a protease inhibitor that blocks HIV protease, preventing viral polyprotein cleavage and maturation; ritonavir is a booster that inhibits cytochrome P450 metabolism to increase atazanavir levels.
Darunavir/r · Juan A. Arnaiz · Infectious Disease
Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Lopinavir and Ritonavir Tablets · DualityBio Inc. · Infectious Disease
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Darunavir (DRV/r) · Community Research Initiative of New England · Infectious Disease
Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Darunavir/Ritonavir (Prezista) · Kowa Research Institute, Inc. · Infectious Disease
Darunavir is an HIV protease inhibitor that blocks the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Lopinavir/ritonavir 4:1 · Drugs for Neglected Diseases · Infectious Disease
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Lopinavir/ritonavir (Kaletra) · Abbott · Infectious Disease
Lopinavir and ritonavir are protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
lopinavir with ritonavir in 1:1 ratio · Drugs for Neglected Diseases · Infectious Disease
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Ritonavir (heat-stable) · Bristol-Myers Squibb · Infectious Disease
Ritonavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Lopinavir / Ritonavir · Baqiyatallah Medical Sciences University · Infectious Disease
Lopinavir and ritonavir are protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
Triple therapy with ritonavir · Sociedad Andaluza de Enfermedades Infecciosas · Infectious Disease
Ritonavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Reducing dose of Lopinavir · University Hospital, Geneva · Infectious Disease
Lopinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and thereby inhibiting HIV replication.
ritonavir-boosted fosamprenavir · The University of Texas Health Science Center, Houston · Infectious Disease
Fosamprenavir is a protease inhibitor that blocks HIV protease, preventing viral replication, and is boosted by ritonavir which inhibits its metabolism to increase drug levels.
Ritonavir (Norvir) · Germans Trias i Pujol Hospital · Infectious Disease
Ritonavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
Telzir® · ViiV Healthcare · Infectious Disease
Telzir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
TMC114/ritonavir · Janssen-Cilag Ltd. · Infectious Disease
TMC114 (darunavir) is a protease inhibitor that blocks HIV protease, preventing viral replication when boosted with ritonavir.
Lopinavir/ritonavir and ritonavir · University of Miami · Infectious Disease
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Prezista® · Geropharm · Infectious Disease
Prezista (darunavir) is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
Atazanavir (Reyataz) · Germans Trias i Pujol Hospital · Infectious Disease
Atazanavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.

Phase 3 pipeline (12)

TMC125, Darunavir; Ritonavir · Tibotec, Inc · Infectious Diseases
TMC125, Darunavir; Ritonavir is a combination of HIV protease inhibitors that work by blocking the protease enzyme, preventing the maturation of viral particles.
Half-boosted Fosamprenavir · GlaxoSmithKline · Infectious Disease
Half-boosted fosamprenavir is an HIV protease inhibitor that blocks viral protease enzyme activity with reduced ritonavir boosting compared to standard fosamprenavir formulations.
LEXIVA (GW433908) · ViiV Healthcare · Infectious Disease
Lexiva is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
Atazanavir (immediate switch) · Bristol-Myers Squibb · Infectious Disease
Atazanavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
Atazanavir/ritonavir monotherapy · IRCCS San Raffaele · Infectious Disease
Atazanavir/ritonavir inhibits HIV protease to prevent viral replication, with ritonavir boosting atazanavir levels through CYP3A4 inhibition.
Darunavir (DRV) · Tibotec Pharmaceuticals, Ireland · Infectious Disease
Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Nelfinavir (NFV) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Infectious Disease
Nelfinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
Full Boosted Fosamprenavir · GlaxoSmithKline · Infectious Disease
Fosamprenavir is a protease inhibitor that, when boosted with ritonavir, blocks HIV protease to prevent viral replication.
Atazanavir capsules · Bristol-Myers Squibb · Infectious Disease
Atazanavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
Atazanavir (Week 24 switch) · Bristol-Myers Squibb · Infectious Disease
Atazanavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
Indinavir (IDV) · French National Agency for Research on AIDS and Viral Hepatitis · Infectious Disease
Indinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
LPV · Bristol-Myers Squibb · Infectious Disease
LPV is a protease inhibitor that blocks HIV protease, preventing the maturation of HIV virions and reducing viral replication.

Phase 2 pipeline (1)

Apomivir® · Far East Bio-Tec Co., Ltd · Infectious Disease
Apomivir is an HIV protease inhibitor that blocks the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.