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Lopinavir and Ritonavir Tablets
Lopinavir and Ritonavir Tablets is a HIV protease inhibitor Small molecule drug developed by DualityBio Inc.. It is currently FDA-approved for HIV-1 infection in combination with other antiretroviral agents. Also known as: Kletra.
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication. Used for HIV-1 infection in treatment-naïve and treatment-experienced patients, HIV-1 infection in combination antiretroviral therapy.
At a glance
| Generic name | Lopinavir and Ritonavir Tablets |
|---|---|
| Also known as | Kletra |
| Sponsor | DualityBio Inc. |
| Drug class | HIV protease inhibitor |
| Target | HIV protease |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Lopinavir inhibits HIV protease, an enzyme essential for cleaving viral polyproteins into functional components needed for infectious particle assembly. Ritonavir is a potent protease inhibitor that also acts as a pharmacokinetic booster, inhibiting cytochrome P450 metabolism to increase lopinavir plasma concentrations. Together, they suppress HIV replication and reduce viral load in infected patients.
Approved indications
- HIV-1 infection in combination with other antiretroviral agents
Common side effects
- Diarrhea
- Nausea
- Abdominal pain
- Headache
- Lipid abnormalities (elevated cholesterol/triglycerides)
- Hepatotoxicity
Key clinical trials
- A Trial of 2 Options for Second Line Combination Antiretroviral Therapy Following Virological Failure of a Standard Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)+2N(t)RTI First Line Regimen (PHASE4)
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- Trial to Evaluate the Interest of a Reductive Anti Retroviral Strategy Using Dual Therapy Inspite of Triple Therapy (PHASE3)
- Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors (PHASE1, PHASE2)
- A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Aluvia (PHASE1)
- Bone and Body Comp: A Sub Study of the SECOND-LINE Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lopinavir and Ritonavir Tablets CI brief — competitive landscape report
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- DualityBio Inc. portfolio CI
Frequently asked questions about Lopinavir and Ritonavir Tablets
What is Lopinavir and Ritonavir Tablets?
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Related
- Drug class: All HIV protease inhibitor drugs
- Target: All drugs targeting HIV protease
- Manufacturer: DualityBio Inc. — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for HIV-1 infection in combination with other antiretroviral agents
- Also known as: Kletra
- Compare: Lopinavir and Ritonavir Tablets vs similar drugs
- Pricing: Lopinavir and Ritonavir Tablets cost, discount & access