Cytochrome P450 3A4 — Drug Target

All drugs that target Cytochrome P450 3A4 — marketed and clinical-stage. Includes 8 drug classes acting on this target.

Drug classes

Azole Antifungal [EPC] · Protease Inhibitor · cyclophosphamide · Amphenicol-class Antibacterial · vindesine · Antimycobacterial · Antimycobacterial [EPC] · indinavir

Marketed (10)

• Vivjoa · Mycovia Pharms · Azole Antifungal [EPC] · Infectious Disease
  Vivjoa works by inhibiting the enzyme Cytochrome P450 3A4, which is involved in the synthesis of ergosterol, a critical component of fungal cell membranes.
• Agenerase · GSK · Protease Inhibitor · Immunology
• Viracept · Agouron Pharms · Protease Inhibitor · Immunology
  Viracept works by blocking the protease enzyme, which is essential for the replication of HIV.
• Cytoxan (Lyophilized) · Baxter · cyclophosphamide · Oncology
  Cytoxan works by interfering with the DNA replication process in rapidly dividing cancer cells.
• Cyclophosphamid · Zhejiang University · Oncology
• Chlorocidin · Parkedale · Amphenicol-class Antibacterial · Neuroscience
• Diflucan · Pfizer · Azole Antifungal [EPC]
• Eldisine · vindesine · Oncology
• Myambutol · Kanchan Hlthcare · Antimycobacterial · Infectious Disease
• Pyrazinamide · Dava Pharms Inc · Antimycobacterial [EPC] · Infectious Disease

Phase 2 pipeline (1)

• Climbazol · Metabolic
  Climbazol works by blocking the action of an enzyme called Cytochrome P450 3A4.