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Lopinavir/ritonavir simplification strategy

Fundación Huésped · FDA-approved active Small molecule

Lopinavir/ritonavir simplification strategy is a Protease inhibitor combination Small molecule drug developed by Fundación Huésped. It is currently FDA-approved for HIV-1 infection (as part of antiretroviral therapy simplification strategy). Also known as: Kaletra monotherapy simplification strategy.

A treatment strategy that simplifies HIV management by optimizing the dosing or administration of lopinavir/ritonavir, a protease inhibitor combination, to improve adherence and reduce pill burden.

A treatment strategy that simplifies HIV management by optimizing the dosing or administration of lopinavir/ritonavir, a protease inhibitor combination, to improve patient adherence and outcomes. Used for HIV-1 infection (as part of antiretroviral therapy simplification).

At a glance

Generic nameLopinavir/ritonavir simplification strategy
Also known asKaletra monotherapy simplification strategy
SponsorFundación Huésped
Drug classProtease inhibitor combination
TargetHIV protease
ModalitySmall molecule
Therapeutic areaInfectious Disease
PhaseFDA-approved

Mechanism of action

Lopinavir/ritonavir is a fixed-dose combination of two HIV protease inhibitors; lopinavir inhibits viral protease and ritonavir acts as a pharmacokinetic booster. This simplification strategy aims to reduce the complexity of antiretroviral regimens, potentially through dose optimization or formulation changes, to enhance patient adherence and clinical outcomes in HIV-infected individuals.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Lopinavir/ritonavir simplification strategy

What is Lopinavir/ritonavir simplification strategy?

Lopinavir/ritonavir simplification strategy is a Protease inhibitor combination drug developed by Fundación Huésped, indicated for HIV-1 infection (as part of antiretroviral therapy simplification strategy).

How does Lopinavir/ritonavir simplification strategy work?

A treatment strategy that simplifies HIV management by optimizing the dosing or administration of lopinavir/ritonavir, a protease inhibitor combination, to improve adherence and reduce pill burden.

What is Lopinavir/ritonavir simplification strategy used for?

Lopinavir/ritonavir simplification strategy is indicated for HIV-1 infection (as part of antiretroviral therapy simplification strategy).

Who makes Lopinavir/ritonavir simplification strategy?

Lopinavir/ritonavir simplification strategy is developed and marketed by Fundación Huésped (see full Fundación Huésped pipeline at /company/fundaci-n-hu-sped).

Is Lopinavir/ritonavir simplification strategy also known as anything else?

Lopinavir/ritonavir simplification strategy is also known as Kaletra monotherapy simplification strategy.

What drug class is Lopinavir/ritonavir simplification strategy in?

Lopinavir/ritonavir simplification strategy belongs to the Protease inhibitor combination class. See all Protease inhibitor combination drugs at /class/protease-inhibitor-combination.

What development phase is Lopinavir/ritonavir simplification strategy in?

Lopinavir/ritonavir simplification strategy is FDA-approved (marketed).

What are the side effects of Lopinavir/ritonavir simplification strategy?

Common side effects of Lopinavir/ritonavir simplification strategy include Diarrhea, Nausea, Lipid abnormalities, Hepatotoxicity, Gastrointestinal disturbance.

What does Lopinavir/ritonavir simplification strategy target?

Lopinavir/ritonavir simplification strategy targets HIV protease and is a Protease inhibitor combination.

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