Beta-2 adrenergic receptor — Drug Target

All drugs that target Beta-2 adrenergic receptor — marketed and clinical-stage. Includes 34 drug classes acting on this target.

Drug classes

beta2-Adrenergic Agonist · Long-acting beta-2 agonist (LABA) · Beta-2 adrenergic agonist (long-acting) · Short-acting beta-2 adrenergic agonist (SABA) · Beta-2 adrenergic agonist (short-acting) · Short-acting beta-2 agonist (SABA) · Long-acting beta-2 adrenergic agonist (LABA) · pronetalol · bitolterol · terbutaline · beta-Adrenergic Agonist · alpha-Adrenergic Blocker [EPC]

Marketed (49)

• Breo Ellipta · Glaxo Grp Ltd · beta2-Adrenergic Agonist · Respiratory
  Breo Ellipta works by stimulating the beta-2 adrenergic receptor to relax airway muscles and improve breathing.
• Formoterol Inhalation Solution · Chiesi Farmaceutici S.p.A. · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Tulobuterol patch with placebo dry syrup · SamA Pharmaceutical Co., Ltd · Beta-2 adrenergic agonist (long-acting) · Respiratory
  Tulobuterol is a beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Ventoline® Evohaler® 100 µg/inhalation pMDI · Orion Corporation, Orion Pharma · Short-acting beta-2 adrenergic agonist (SABA) · Respiratory / Pulmonology
  Albuterol (salbutamol) is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle to rapidly relieve bronchospasm and improve airflow.
• Albuterol-HFA-MDI · Teva Branded Pharmaceutical Products R&D, Inc. · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Albuterol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• ProAir® HFA · Teva Branded Pharmaceutical Products R&D, Inc. · Short-acting beta-2 agonist (SABA) · Respiratory / Pulmonology
  ProAir HFA is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle to rapidly relieve bronchospasm and improve airflow in the lungs.
• Nebulized Salbutamol · Hospital General Naval de Alta Especialidad - Escuela Medico Naval · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Salbutamol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• Arformoterol Tartrate Inhalation Solution · Sumitomo Pharma America, Inc. · Long-acting beta-2 adrenergic agonist (LABA) · Respiratory / Pulmonology
  Arformoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Servent Diskus · Teva Branded Pharmaceutical Products R&D, Inc. · Long-acting beta-2 agonist (LABA) · Respiratory / Pulmonology
  Salmeterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing bronchodilation and improved airflow.
• Arcapta Neohaler · Novartis · beta2-Adrenergic Agonist · Respiratory
• salbutamol pressurized metered dose inhaler · University of Saskatchewan · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Salbutamol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• COPD rescue medications · GlaxoSmithKline · Short-acting beta-2 agonist (SABA) · Respiratory/Pulmonology
  COPD rescue medications are short-acting beta-2 agonists (SABAs) that rapidly relax airway smooth muscle to provide quick relief of acute bronchospasm and breathing difficulty.
• Striverdi Respimat · Boehringer Ingelheim · beta2-Adrenergic Agonist · Respiratory
  Striverdi Respimat works by stimulating the beta-2 receptors in the lungs to relax airway muscles and improve breathing.
• xopenex · Phoenix Children's Hospital · Respiratory
• Nethalide · pronetalol · Other
• Tornalate · Sanofi · bitolterol · Respiratory
• Brethine · terbutaline · Respiratory
• Xolaam® · AstraZeneca · Long-acting beta-2 agonist (LABA) · Respiratory / Pulmonology
  Xolaam is a long-acting beta-2 agonist that binds to beta-2 adrenergic receptors on airway smooth muscle to promote bronchodilation and improve airflow in respiratory disease.
• Indacaterol Fumarate · University of Milan · Long-acting beta-2 agonist (LABA) · Respiratory
  Indacaterol fumarate is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Dobutamine Hydrochloride In Dextrose 5% In Plastic Container · beta-Adrenergic Agonist · Cardiovascular
• Formoterol stada · Fundacio Privada Mon Clinic Barcelona · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Ventolin® · AstraZeneca · Short-acting beta-2 agonist (SABA) · Respiratory
  Ventolin is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle by stimulating beta-2 receptors, rapidly opening constricted airways.
• Proventil · Merck & Co. · beta2-Adrenergic Agonist · Cardiovascular
• Formoterol fumerate · Novartis · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol fumarate is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Albuterol/salbutamol MDI · GlaxoSmithKline · Short-acting beta-2 agonist (SABA) · Respiratory
  Albuterol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing rapid relaxation and bronchodilation.
• Metaproterenol · beta2-Adrenergic Agonist · Respiratory
• Proventil® HFA · Teva Branded Pharmaceutical Products R&D, Inc. · Short-acting beta-2 agonist (SABA) · Respiratory / Pulmonology
  Proventil HFA is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle to rapidly relieve bronchospasm and improve airflow.
• Albuterol/salbutamol MDIs · GlaxoSmithKline · Short-acting beta-2 agonist (SABA) · Respiratory
  Albuterol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing rapid relaxation and bronchodilation.
• Arformoterol (Brovana) · Trinity Health Of New England · Long-acting beta-2 agonist (LABA) · Respiratory
  Arformoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Brovana · Lupin · beta2-Adrenergic Agonist · Cardiovascular
  Brovana works by activating the beta-2 adrenergic receptor to relax airway muscles and improve breathing.
• Coreg · Waylis · alpha-Adrenergic Blocker [EPC] · Cardiovascular
  Coreg works by blocking the effects of the hormone epinephrine on the heart, reducing its workload and improving its function.
• formoterol Turbuhaler 9µg · AstraZeneca · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• Dobutamine Hydrochloride In Dextrose 5% In Plastic Container · Pfizer · beta-adrenergic agonist
• Xopenex · Oak Pharms Inc · beta2-Adrenergic Agonist · Respiratory
  Xopenex works by activating the beta-2 adrenergic receptor, leading to bronchodilation and relaxation of airway smooth muscle.
• Lavopa · Pfizer · ritodrine · Other
• Formoterol Aldo · Fundacio Privada Mon Clinic Barcelona · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Salmeterol (DISKUS) · GlaxoSmithKline · Long-acting beta-2 agonist (LABA) · Respiratory
  Salmeterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• Perforomist, nebulization, COPD · Dey · Long-acting beta-2 agonist (LABA) · Respiratory
  Perforomist is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow in COPD patients.
• long acting beta agonist · University of Alberta · Long-acting beta-2 agonist (LABA) · Respiratory / Pulmonology
  Long-acting beta agonists bind to beta-2 adrenergic receptors on airway smooth muscle, causing prolonged relaxation and bronchodilation.
• Betagan · AbbVie · beta-Adrenergic Blocker · Cardiovascular

Phase 3 pipeline (41)

• [F-18]Flornaptitril · CereMark Pharma, LLC · beta-2 adrenergic receptor agonist · Cardiovascular
  Flornaptitril is a beta-2 adrenergic receptor agonist.
• Salmeterol MDI · Sumitomo Pharma America, Inc. · Long-acting beta-2 agonist (LABA) · Respiratory
  Salmeterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Levalbuterol UDV TID · Sumitomo Pharma America, Inc. · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Levalbuterol is a selective beta-2 adrenergic agonist that relaxes airway smooth muscle to improve breathing in patients with obstructive airway disease.
• Formoterol Turbuhaler 4.5 µg · AstraZeneca · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• Formoterol fumarate 10 · SkyePharma AG · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol fumarate is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Formoterol 12 ųg BID · Sumitomo Pharma America, Inc. · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• albuterol aerosol by HFA MDI · Teva Branded Pharmaceutical Products R&D, Inc. · Beta-2 adrenergic agonist · Respiratory
  Albuterol works by stimulating the beta-2 adrenergic receptors in the lungs, causing bronchodilation and relaxation of bronchial smooth muscle.
• Inhaled Long-Acting Beta Agonist · Sanofi · Long-acting beta-2 agonist (LABA) · Respiratory
  Long-acting beta-2 agonists bind to beta-2 adrenergic receptors on airway smooth muscle, causing relaxation and bronchodilation with sustained effect over 12-24 hours.
• Formoterol powder 12 µg/unit dose · Chiesi Farmaceutici S.p.A. · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing bronchodilation and improved airflow.
• Placebo to Formoterol · Novartis · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• epinephrine inhalation aerosol · Amphastar Pharmaceuticals, Inc. · Adrenergic agonist · Respiratory
  Epinephrine inhalation aerosol works by stimulating the beta-2 adrenergic receptors in the lungs to cause bronchodilation.
• Salbutamol as needed · GlaxoSmithKline · Beta-2 adrenergic receptor agonist · Respiratory
  Salbutamol is a short-acting beta-2 adrenergic receptor agonist that works by relaxing bronchial muscles to improve airflow to the lungs.
• Albuterol/salmeterol HFA MDI · Teva Branded Pharmaceutical Products R&D, Inc. · Beta-2 adrenergic agonist combination (SABA/LABA) · Respiratory/Pulmonology
  Albuterol and salmeterol are beta-2 adrenergic agonists that relax airway smooth muscle to improve breathing, with albuterol providing rapid relief and salmeterol offering sustained bronchodilation.
• Salbutamol HFA-152a · GlaxoSmithKline · Beta-2 adrenergic receptor agonist · Respiratory
  Salbutamol HFA-152a is a short-acting beta-2 adrenergic receptor agonist that works by relaxing bronchial muscles to improve airflow to the lungs.
• Levalbuterol HCl Inhalation Solution · Sumitomo Pharma America, Inc. · Beta-2 adrenergic receptor agonist (short-acting bronchodilator) · Respiratory
  Levalbuterol is a selective beta-2 adrenergic receptor agonist that relaxes airway smooth muscle to improve breathing.
• albuterol inhalation aerosol · Amphastar Pharmaceuticals, Inc. · Beta-2 adrenergic receptor agonist · Respiratory
  Albuterol inhalation aerosol is a beta-2 adrenergic receptor agonist that works by relaxing bronchial muscles to improve airflow to the lungs.
• Salmeterol Inhalation Powder · GlaxoSmithKline · Long-acting beta-2 agonist (LABA) · Respiratory
  Salmeterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Procaterol, Salbultamol · PT Otsuka Indonesia · Beta-2 adrenergic receptor agonist · Respiratory
  Procaterol is a beta-2 adrenergic receptor agonist, and Salbutamol is a beta-2 adrenergic receptor agonist.
• budesonode bid + terbutaline 'as needed' · AstraZeneca · Corticosteroid + Beta-2 adrenergic receptor agonist · Respiratory
  Budesonide is a corticosteroid that reduces inflammation, while terbutaline is a beta-2 adrenergic receptor agonist that relaxes airway muscles.
• long-acting beta-agonists · Genentech, Inc. · Long-acting beta-2 agonist (LABA) · Respiratory / Pulmonology
  Long-acting beta-agonists bind to beta-2 adrenergic receptors on airway smooth muscle to cause sustained bronchodilation and improve airflow.
• Formoterol (Oxis Turbuhaler®) · Henan University of Traditional Chinese Medicine · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• GW642444 25 · GlaxoSmithKline · Long-acting beta-2 agonist (LABA) · Respiratory / Pulmonology
  GW642444 is a long-acting beta-2 adrenergic receptor agonist that stimulates bronchial smooth muscle relaxation to improve airflow in respiratory disease.
• Levalbuterol tartrate HFA MDI · Sumitomo Pharma America, Inc. · Beta-2 adrenergic receptor agonist (short-acting bronchodilator) · Respiratory
  Levalbuterol is a selective beta-2 adrenergic receptor agonist that relaxes airway smooth muscle to improve breathing.
• beclomethasone/salbutamol combination · Chiesi Farmaceutici S.p.A. · Corticosteroid/beta-2 adrenergic receptor agonist combination · Respiratory
  Beclomethasone is a corticosteroid that reduces inflammation, while salbutamol is a beta-2 adrenergic receptor agonist that relaxes airway smooth muscle.
• GW685698/GW642444 · GlaxoSmithKline · Long-acting beta-2 agonist (LABA) · Respiratory
  GW685698/GW642444 is a long-acting beta-2 adrenergic agonist that stimulates beta-2 receptors on airway smooth muscle to produce bronchodilation.
• Levalbuterol/Levosalbutamol · Sanofi · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Levalbuterol is the active R-enantiomer of albuterol that selectively binds to beta-2 adrenergic receptors on airway smooth muscle to cause bronchodilation.
• albuterol aerosol by HFA BOI · Teva Branded Pharmaceutical Products R&D, Inc. · Beta-2 adrenergic receptor agonist · Respiratory
  Albuterol works by stimulating the beta-2 receptors in the lungs, causing bronchodilation and relaxation of bronchial smooth muscle.
• racemic albuterol MDI · Sumitomo Pharma America, Inc. · Beta-2 adrenergic agonist (short-acting bronchodilator) · Respiratory
  Racemic albuterol is a beta-2 adrenergic agonist that relaxes airway smooth muscle to relieve bronchospasm and improve airflow in obstructive airway diseases.
• Arformoterol 25 ųg BID · Sumitomo Pharma America, Inc. · Long-acting beta-2 agonist (LABA) · Respiratory
  Arformoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Formoterol 12 µg DPI · Chiesi Farmaceutici S.p.A. · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Formoterol MDI · Organon and Co · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Racemic Albuterol · Sumitomo Pharma America, Inc. · Beta-2 adrenergic agonist (short-acting) · Respiratory
  Racemic albuterol is a beta-2 adrenergic agonist that relaxes airway smooth muscle to improve breathing.
• albuterol inhalation powder · Amphastar Pharmaceuticals, Inc. · Beta-2 adrenergic agonist (short-acting bronchodilator) · Respiratory
  Albuterol is a beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle, causing relaxation and bronchodilation.
• albuterol (Ventolin) · AstraZeneca · beta-2 adrenergic receptor agonist · Respiratory
  Albuterol is a beta-2 adrenergic receptor agonist that works by relaxing bronchial muscles and increasing air flow to the lungs.
• Meptin® Swinghaler · Taiwan Otsuka Pharm. Co., Ltd · Beta-2 adrenergic agonist (short-acting or long-acting bronchodilator) · Respiratory / Pulmonology
  Meptin is a beta-2 adrenergic agonist that relaxes airway smooth muscle to improve breathing in respiratory conditions.
• Ventolin® MDI · Taiwan Otsuka Pharm. Co., Ltd · Beta-2 adrenergic agonist (short-acting bronchodilator) · Respiratory / Pulmonology
  Ventolin MDI delivers albuterol (salbutamol), a beta-2 adrenergic agonist that relaxes airway smooth muscle to rapidly relieve bronchospasm and improve airflow.
• Terbutaline Turbuhaler · AstraZeneca · Beta-2 adrenergic receptor agonist · Respiratory
  Terbutaline is a beta-2 adrenergic receptor agonist that works by relaxing the muscles in the airways and increasing air flow to the lungs.
• Terbutaline sulphate · AstraZeneca · Beta-2 adrenergic receptor agonist · Respiratory
  Terbutaline sulphate is a beta-2 adrenergic receptor agonist that works by stimulating the beta-2 receptors in the lungs to cause bronchodilation.
• Indacaterol (QAB149) · Novartis · Long-acting beta-2 agonist (LABA) · Respiratory
  Indacaterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.
• Formoterol (OT) · AstraZeneca · Long-acting beta-2 agonist (LABA) · Respiratory
  Formoterol is a long-acting beta-2 adrenergic agonist that binds to beta-2 receptors on airway smooth muscle to cause bronchodilation and improve airflow.

Phase 2 pipeline (5)

• Isophenethanol · nifenalol · Other
  Nifenalol is thought to work by interacting with cellular pathways, although the exact mechanism is unknown.
• Bupranol · bupranolol · Cardiovascular
  Bupranol works by blocking the beta-2 adrenergic receptor, which helps to reduce the pressure in the eye and lower blood pressure.
• Arm T1: Primatene Mist HFA · Amphastar Pharmaceuticals, Inc. · Sympathomimetic agent · Respiratory
  Primatene Mist HFA is a bronchodilator that contains epinephrine, which works by relaxing the muscles in the airways and increasing air flow to the lungs.
• Epiferol · reproterol · Respiratory
  Epiferol works by stimulating the beta-2 adrenergic receptor to increase the concentration of cyclic AMP, leading to bronchodilation.
• Combination DSCG and Reproterol · MEDA Pharma GmbH & Co. KG · mast cell stabilizer and beta-2 adrenergic receptor agonist · Respiratory
  DSCG inhibits mast cell degranulation and reduces inflammation, while Reproterol is a beta-2 adrenergic receptor agonist that relaxes bronchial smooth muscle.

Phase 1 pipeline (1)

• Asthma reliever and controller · Ivan Sofian Wibowo · Bronchodilator · Respiratory
  Bronchodilator