Last reviewed · How we verify
Ventolin®
Ventolin is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle by stimulating beta-2 receptors, rapidly opening constricted airways.
Ventolin is a short-acting beta-2 adrenergic agonist that relaxes airway smooth muscle by stimulating beta-2 receptors, rapidly opening constricted airways. Used for Acute asthma exacerbations and bronchospasm, Maintenance therapy for chronic asthma, Exercise-induced bronchoconstriction.
At a glance
| Generic name | Ventolin® |
|---|---|
| Also known as | salbutamol, Salbutamol, Salbutamol sulphate aerosol, Ventolin (salbutamol) |
| Sponsor | AstraZeneca |
| Drug class | Short-acting beta-2 agonist (SABA) |
| Target | Beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | FDA-approved |
Mechanism of action
The drug binds to and activates beta-2 adrenergic receptors on bronchial smooth muscle cells, triggering a cascade that increases intracellular cAMP levels. This leads to smooth muscle relaxation and bronchodilation, providing rapid relief of airway obstruction. Ventolin is used as a rescue medication for acute bronchospasm and asthma symptoms.
Approved indications
- Acute asthma exacerbations and bronchospasm
- Maintenance therapy for chronic asthma
- Exercise-induced bronchoconstriction
Common side effects
- Tremor
- Headache
- Nervousness or anxiety
- Palpitations
- Muscle cramps
Key clinical trials
- Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma. (PHASE3)
- Clinical Assessment of Acupuncture for the Treatment of Chronic Asthma (NA)
- A Study to Evaluate the Efficacy and Safety of QVM149 (Indacaterol Acetate / Glycopyrronium Bromide / Mometasone Furoate) Versus Salmeterol Xinafoate/Fluticasone Propionate in Children From 12 Years to Less Than 18 Years of Age With Asthma. (PHASE3)
- Effect of Intraoperative Salbutamol Administration on Mechanical Power and Respiratory Mechanics in Obese Patients Undergoing Laparoscopic Bariatric Surgery (NA)
- Evaluation of the Effectiveness of the Nebulization Bronchodilators Under High Nasal Flow Humidified (NA)
- the Inhaled β2-adrenergic Receptor Agonist for Transient Tachypnoea of the Newborn (the REFSAL Trial) (PHASE3)
- Efficacy of Fluticasone Propionate Associated With Salmeterol Using Inhalation Chamber Versus Placebo to Improve the Respiratory Function in Children Over Six Years of Age Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation With a Decline of FEV1 ≥10% From Pre Transplantation (PHASE3)
- A Study Evaluating the Effect of Inhaled PT007(AS MDI) Versus Placebo MDI and Ventolin Evohaler on Lung Function in Adult Participants With Asthma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |