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Dobutamine Hydrochloride In Dextrose 5% In Plastic Container (Dobutamine Hydrochloride)
Dobutamine Hydrochloride In Dextrose 5% In Plastic Container (generic name: Dobutamine Hydrochloride) is a beta-adrenergic agonist Small molecule drug developed by Pfizer. It is currently FDA-approved (first approved 1993) for Acute myocardial infarction, Cardiogenic shock, Heart failure.
Dobutamine Hydrochloride is a medication used to treat cardiogenic shock and severe heart failure. It is administered via IV and has a short half-life of two minutes. The drug is generally used short-term, but may be used for longer periods in certain cases. It is used in cardiac stress tests and has an onset of effects within 2 minutes. The medication is given as a continuous infusion and the dose needs to be adjusted to the desired effect. It is used to improve cardiac output in patients with heart failure. Pfizer Inc. markets this drug.
At a glance
| Generic name | Dobutamine Hydrochloride |
|---|---|
| Sponsor | Pfizer |
| Drug class | beta-adrenergic agonist |
| Target | Beta-2 adrenergic receptor |
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 1993 |
Approved indications
- Acute myocardial infarction
- Cardiogenic shock
- Heart failure
- Low cardiac output syndrome
- Postcardiotomy low output syndrome
- Severe heart failure
Common side effects
- Increased Heart Rate
- Increased Blood Pressure
- Ventricular Ectopic Activity
- Hypotension
- Stress Cardiomyopathy
- Phlebitis
- Local Inflammatory Changes
- Nausea
- Headache
- Anginal Pain
- Nonspecific Chest Pain
- Palpitations
Drug interactions
- dobutamine
Key clinical trials
- Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock (NA)
- Artificial Intelligence Stress Echo (FINESSE) Project
- Impact Of Using LevosemidanVersus DobutamineOn Right Ventricular Function In AdultPatients Undergoing Elective Valve Replacement Surgery
- The PROTECT-HIE Trial (PHASE2)
- Cerebral Oxygen Saturation Monitoring In Cardiac Surgery (COSMICS) (NA)
- Intraoperative Multimodal Monitoring as a Means in Reducing the Duration of Mechanical Ventilation in High-Risk Patients Undergoing Major Abdominal Procedures - A Pilot Study (NA)
- Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
- Comparison Bewteen Intraoperative HPI vs. High Mean Arterial Pressure Threshold (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dobutamine Hydrochloride In Dextrose 5% In Plastic Container CI brief — competitive landscape report
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- Pfizer portfolio CI
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Related
- Drug class: All beta-adrenergic agonist drugs
- Target: All drugs targeting Beta-2 adrenergic receptor
- Manufacturer: Pfizer — full pipeline
- Indication: Drugs for Acute myocardial infarction
- Indication: Drugs for Cardiogenic shock
- Indication: Drugs for Heart failure
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