How many drugs are losing patent protection in 2027?

Drug Landscape tracks 60 marketed drugs with at least one patent expiring in 2027, sourced from FDA Orange Book + USPTO Patent Public Search.

What is a patent cliff?

A patent cliff is the year a major branded drug loses primary patent protection, opening the market to generic or biosimilar entry. Originator revenue typically drops 30–80% within 24 months, depending on the drug class and the strength of secondary patents.

Are these forecasts accurate?

Patent expiry dates are deterministic — they're the listed expiry from the Orange Book or USPTO record. Generic / biosimilar entry timing depends on litigation outcomes, paragraph IV challenges, settlements, and exclusivity periods which can shift the practical "cliff" by months to years.

Last reviewed 2026-05-14 · How we verify

2027 Pharmaceutical Patent Cliff

60 marketed drugs with patents expiring in 2027, joined to sponsor + therapeutic area + drug class. Forward-looking forecast. Sourced from FDA Orange Book + USPTO Patent Public Search.

60 drugs 164 patents 12 therapeutic areas Forward-looking

By therapeutic area

Oncology (14)

2027-01-06 — Camptosar · Pfizer · Topoisomerase Inhibitor · Compound
2027-01-06 — Camptosar · Pfizer · Topoisomerase Inhibitor
2027-01-25 — Duragesic · Johnson & Johnson (Janssen Pharmaceutica) · Synthetic opioid analgesic · Formulation
2027-02-13 — Taxol · Pfizer · Microtubule Inhibitor [EPC] · Compound
2027-02-13 — Taxol · Pfizer · Microtubule Inhibitor
2027-03-22 — Arthrotec · Pfizer · diclofenac
2027-06-12 — Elocon · Merck & Co. · Corticosteroid · Formulation
2027-07-24 — Rowasa · Meda Pharms · Aminosalicylate [EPC]
2027-08-03 — Deltasone · Generic (originally Schering) · Corticosteroid [EPC] · Method of Use
2027-08-12 — Derma-Smoothe/Fs · Eurofarma · Corticosteroid [EPC] · Formulation
2027-08-13 — Xtandi · Astellas Pharma · Androgen receptor inhibitor
2027-08-13 — Verdeso · Padagis Us · Corticosteroid [EPC] · Formulation
2027-11-03 — Sandimmune · Novartis · Calcineurin Inhibitor Immunosuppressant [EPC]
2027-12-11 — TELOTRISTAT ETIPRATE · Serotonin Synthesis Inhibitor · Compound

Metabolic (12)

2027-01-24 — Beconase Aq · Corticosteroid
2027-01-26 — Cystagon · Mylan · Cystine Depleting Agent
2027-02-18 — Byetta · AstraZeneca · GLP-1 Receptor Agonist [EPC]
2027-02-27 — Ozempic · Novo Nordisk · GLP-1 Receptor Agonist [EPC]
2027-03-10 — Premarin · Pfizer · Estrogen [EPC]
2027-03-15 — Amphetamine Sulfate · UCB · Central Nervous System Stimulant
2027-04-15 — Tradjenta · Boehringer Ingelheim · Dipeptidyl Peptidase 4 Inhibitor [EPC]
2027-04-25 — Zuragard · isopropanol
2027-05-02 — Lyrica · Pfizer Inc. · Anticonvulsant, analgesic · Compound
2027-05-12 — Ongentys · Neurocrine Biosciences · Catechol-O-Methyltransferase Inhibitor [EPC]
2027-09-03 — Keppra · Generic (originally UCB Pharma) · Antiepileptic agent · Formulation
2027-12-19 — Vantobra · Pfizer · tobramycin

Immunology (8)

2027-02-14 — AVACINCAPTAD PEGOL SODIUM · Complement Inhibitors · Compound
2027-02-28 — Tussionex Pennkinetic · Bayer · Histamine-1 Receptor Antagonist
2027-06-01 — Acetaminophen · Polymedica · acetaminophen
2027-07-24 — MESALAMINE · Aminosalicylate [EPC] · Compound
2027-08-01 — Salonpas · Non-Standardized Plant Allergenic Extract [EPC]
2027-08-01 — Salonpas · Hisamitsu Pharm Co · methyl salicylate
2027-11-03 — Sandimmune · Novartis AG (originally Sandoz) · Calcineurin inhibitor (immunosuppressant) · Formulation
2027-12-28 — Tracleer · AstraZeneca · Endothelin Receptor Antagonist · Formulation

Neuroscience (7)

2027-01-10 — Subutex · Purdue Pharma Lp · Partial Opioid Agonist · Formulation
2027-02-27 — Bupivacaine Hydrochloride And Epinephrine · Pfizer Inc. · alpha-Adrenergic Agonist [EPC] · Formulation
2027-03-02 — Abilify · Generic (originally Otsuka/BMS) · Third-generation antipsychotic (D2 partial agonist) · Method of Use
2027-04-17 — Catapres-Tts-1 · Lavipharm · Central alpha-2 Adrenergic Agonist · Formulation
2027-04-30 — Amyvid · Avid Radiopharms Inc · Radioactive Diagnostic Agent [EPC]
2027-11-12 — Risperdal · Johnson & Johnson (Janssen) · Atypical Antipsychotic [EPC] · Formulation
2027-11-16 — Topamax · Janssen · Formulation

Cardiovascular (6)

2027-02-27 — Epipen · Pfizer Inc. · alpha-Adrenergic Agonist [EPC] · Formulation
2027-03-31 — Proventil · Merck & Co. · beta2-Adrenergic Agonist
2027-04-18 — NICARDIPINE HYDROCHLORIDE · Calcium channel blocker · Method of Use
2027-04-26 — Zocor · Merck & Co. · HMG-CoA Reductase Inhibitor [EPC] · Formulation
2027-08-31 — Pradaxa · Boehringer Ingelheim · Direct thrombin inhibitor
2027-09-26 — Argatroban · Hikma Pharm Co Ltd · Anti-coagulant [EPC] · Formulation

Bone (3)

2027-02-07 — Jadelle · Fdn Consumer · Progestin · Formulation
2027-03-10 — Duavee · Wyeth Pharms Pfizer · Estrogen [EPC]
2027-06-01 — Ortho-Novum 10/11-21 · Merck & Co. · Estrogen

Respiratory (3)

2027-04-09 — Symdeko (Copackaged) · Vertex Pharms
2027-04-09 — Trikafta (Copackaged) · Vertex Pharms Inc
2027-06-14 — Breo Ellipta · Glaxo Grp Ltd · beta2-Adrenergic Agonist

Pain (2)

2027-02-20 — Naloxone Hydrochloride · Pfizer Inc. · Mixed opioid agonist-antagonist with opioid antagonist · Formulation
2027-07-23 — Subutex · Indivior · partial opioid agonist · Formulation

Infectious Disease (2)

2027-05-07 — Amoxil · Generic (originally Beecham/GSK) · Aminopenicillin (Beta-lactam antibiotic) · Method of Use
2027-12-19 — Vibramycin · Generic (originally Pfizer) · Tetracycline antibiotic · Formulation

Nephrology (1)

2027-02-02 — Rayaldee · calcifediol · Formulation

Gastroenterology (1)

2027-09-02 — Xifaxan · Bausch Health · Rifamycin Antibacterial [EPC] · Compound