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Acetaminophen (Paracetamol)
Acetaminophen works by blocking pain signals in the brain.
The provided FDA label for Paracetamol (Acetaminophen) contains only the Indications and Usage section. The drug is indicated for temporary relief of minor aches and pains including headache, muscular aches, backache, arthritis pain, cold symptoms, toothache, and menstrual cramps, as well as fever reduction. Critical sections including Mechanism of Action, Pharmacokinetics, Contraindications, Adverse Reactions, and Drug Interactions are not available in the provided text. Without these sections, a complete safety and efficacy profile cannot be established.
At a glance
| Generic name | Paracetamol |
|---|---|
| Also known as | Parol, Paracetamol Saft Hexal, Perfalgan, Acetaminophen, Acephen |
| Sponsor | Polymedica |
| Drug class | acetaminophen |
| Target | Transient receptor potential cation channel subfamily V member 4 |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
| First approval | 1968 |
Mechanism of action
Mechanismof Action. Hydrocodone is full opioid agonist with relative selectivity for the mu-opioid (u) receptor, although it can interact with other opioid receptors at higher doses. The principal therapeutic action of hydrocodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with hydrocodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression.The precise mechanism of the analgesic action is unknown. However, specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified throughout the brain and spinal cord and are thought to play role in the analgesic effects of this drug. The precise mechanism of the analgesic properties of acetaminophen is not established but is thought to involve central actions.
Approved indications
- Allergic rhinitis
- Arthritic Pain
- Backache
- Common cold
- Fever
- Headache disorder
- Influenza-like symptoms
- Joint pain
- Migraine
- Pain
- Pain Treatment Adjunct
- Sinus headache
- Tension-type headache
- Toothache
Common side effects
Drug interactions
- isoniazid
- sulfinpyrazone
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| FDA Orange Book | Patents + exclusivity |