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AVACINCAPTAD PEGOL SODIUM
Avacincaptad pegol sodium is an investigational drug with no FDA approval or label. It is being studied for its potential in treating various ophthalmic conditions, particularly those involving the retina. The drug's mechanism of action involves inhibiting complement activation, which is a key component of the immune system that can contribute to inflammation and tissue damage. Despite promising preclinical and early clinical results, the drug is still in development, and its safety and efficacy profiles are not yet fully established. The lack of an FDA label indicates that it has not yet been approved for any specific use, and its commercial prospects remain uncertain.
At a glance
| Generic name | AVACINCAPTAD PEGOL SODIUM |
|---|---|
| Drug class | Complement Inhibitors |
| Target | Complement C5 |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
| First approval | 2023 |
Approved indications
- Geographic atrophy secondary to age-related macular degeneration
Pipeline indications
Common side effects
- Conjunctival hemorrhage
- Blurred vision
- Increased IOP
- Choroidal neovascularization
- Punctate keratitis
- Eye pain
- Retinal hemorrhage
- Vitreous floaters
- Ocular hypertension
- Blepharitis
- Corneal abrasion
Serious adverse events
- Endophthalmitis
- Retinal detachment
- Vitreous hemorrhage
- Optic ischemic neuropathy
- Vitritis
- Vitreal cells
- Photopsia
Patents
| Patent | Expiry | Type |
|---|---|---|
| 11491176 | 2034-07-11 | Method of Use |
| 11273171 | 2034-07-11 | Method of Use |
| 9617546 | 2027-02-14 | Compound |
| 8236773 | 2026-11-11 | Method of Use |
| 12016875 | 2034-07-11 | Method of Use |
| 7579456 | 2027-02-14 | Compound |
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- AVACINCAPTAD PEGOL SODIUM CI brief — competitive landscape report
- AVACINCAPTAD PEGOL SODIUM updates RSS · CI watch RSS