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Suprane (desflurane), Baxter
Suprane (desflurane), Baxter is a Volatile anesthetic Small molecule drug developed by Medical University of Gdansk. It is currently FDA-approved for Induction and maintenance of general anesthesia in adults and children. Also known as: desflurane.
Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Desflurane is a small molecule that acts as a positive modulator of the glycine receptor (alpha-1/beta). It is used in anesthesia, particularly with the use of a laryngeal mask airway, and has been studied in various clinical trials for conditions such as postoperative cognitive dysfunction and mechanical ventilation complications.
At a glance
| Generic name | Suprane (desflurane), Baxter |
|---|---|
| Also known as | desflurane |
| Sponsor | Medical University of Gdansk |
| Drug class | Volatile anesthetic |
| Target | GABA-A receptor, NMDA receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Desflurane is a halogenated ether volatile anesthetic that acts on multiple ion channels and neurotransmitter receptors in the brain to produce rapid anesthesia and unconsciousness. It enhances the activity of inhibitory GABA-A receptors while simultaneously blocking excitatory NMDA glutamate receptors, resulting in profound CNS depression. The exact molecular mechanism remains incompletely understood but involves modulation of multiple neuronal targets rather than a single receptor.
Approved indications
- Induction and maintenance of general anesthesia in adults and children
Common side effects
- Emergence agitation
- Postoperative nausea and vomiting
- Airway irritation
- Hypotension
- Tachycardia
Key clinical trials
- Early Cognitive Function in Elderly Patients After Laser Laryngeal Surgery: Des vs Prop (PHASE4)
- Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation (NA)
- Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia (PHASE3)
- Early Postoperative Cognitive Dysfunction After Closed Loop Anesthesia vs Inhalational Anesthesia or TIVA (NA)
- Desflurane Versus Propofol Anesthesia for Off-Pump CABG (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Suprane (desflurane), Baxter CI brief — competitive landscape report
- Suprane (desflurane), Baxter updates RSS · CI watch RSS
- Medical University of Gdansk portfolio CI
Frequently asked questions about Suprane (desflurane), Baxter
What is Suprane (desflurane), Baxter?
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Related
- Drug class: All Volatile anesthetic drugs
- Target: All drugs targeting GABA-A receptor, NMDA receptor
- Manufacturer: Medical University of Gdansk — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction and maintenance of general anesthesia in adults and children
- Also known as: desflurane
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing