{"id":"suprane-desflurane-baxter","safety":{"commonSideEffects":[{"rate":null,"effect":"Emergence agitation"},{"rate":null,"effect":"Postoperative nausea and vomiting"},{"rate":null,"effect":"Airway irritation"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Tachycardia"}]},"_chembl":{"chemblId":"CHEMBL1200733","moleculeType":"Small molecule","molecularWeight":"168.04"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desflurane is a halogenated ether volatile anesthetic that acts on multiple ion channels and neurotransmitter receptors in the brain to produce rapid anesthesia and unconsciousness. It enhances the activity of inhibitory GABA-A receptors while simultaneously blocking excitatory NMDA glutamate receptors, resulting in profound CNS depression. The exact molecular mechanism remains incompletely understood but involves modulation of multiple neuronal targets rather than a single receptor.","oneSentence":"Desflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:10:09.366Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia in adults and children"}]},"trialDetails":[{"nctId":"NCT03194074","phase":"PHASE4","title":"Early Cognitive Function in Elderly Patients After Laser Laryngeal Surgery: Des vs Prop","status":"UNKNOWN","sponsor":"Eye & ENT Hospital of Fudan University","startDate":"2017-08-15","conditions":"Cognition Disorders in Old Age","enrollment":70},{"nctId":"NCT02191371","phase":"NA","title":"Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-07","conditions":"Mechanical Ventilation Complication","enrollment":104},{"nctId":"NCT02322502","phase":"PHASE3","title":"Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia","status":"COMPLETED","sponsor":"RWTH Aachen University","startDate":"2015-02","conditions":"Anesthesia With Use of LMA (Laryngeal Mask Airway)","enrollment":352},{"nctId":"NCT02656901","phase":"NA","title":"Early Postoperative Cognitive Dysfunction After Closed Loop Anesthesia vs Inhalational Anesthesia or TIVA","status":"COMPLETED","sponsor":"University of Foggia","startDate":"2016-01","conditions":"Postoperative Cognitive Dysfunction","enrollment":132},{"nctId":"NCT00528515","phase":"PHASE4","title":"Desflurane Versus Propofol Anesthesia for Off-Pump CABG","status":"COMPLETED","sponsor":"Medical University of Gdansk","startDate":"2007-02","conditions":"Coronary Artery Disease","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["desflurane"],"phase":"marketed","status":"active","brandName":"Suprane (desflurane), Baxter","genericName":"Suprane (desflurane), Baxter","companyName":"Medical University of Gdansk","companyId":"medical-university-of-gdansk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desflurane is a small molecule that acts as a positive modulator of the glycine receptor (alpha-1/beta). It is used in anesthesia, particularly with the use of a laryngeal mask airway, and has been studied in various clinical trials for conditions such as postoperative cognitive dysfunction and mechanical ventilation complications.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}