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NCT03194074: POCDLLS
Early Cognitive Function and Recovery in Elderly Patients After Laser Laryngeal Surgery: Desflurane-based vs Propofol-based Anesthesia
Phase 4 trial testing Propofol in Cognition Disorders in Old Age in 70 participants. Status unknown.
1 June 2019
Quick facts
| Lead sponsor | Eye & ENT Hospital of Fudan University |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 70 |
| Start date | 15 August 2017 |
| Primary completion | 1 June 2019 |
| Estimated completion | 1 December 2019 |
| Sites | 1 location across China |
Drugs / interventions tested
- Propofol (Propofol) — full drug profile →
- Desflurane (DESFLURANE) — full drug profile →
Conditions studied
- Cognition Disorders in Old Age — all drugs for Cognition Disorders in Old Age →
Sponsor
Eye & ENT Hospital of Fudan University
Who can join
60 and older, any sex, with Cognition Disorders in Old Age. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Change of Mini-Mental State (MMS) test score
Time frame: Change of MMS score between two time points (the day before surgery and 30min postoperatively
Change of 30-point questionnaire that is used to measure cognitive impairment before and after surgery
Sponsor's own description
Postoperative cognitive impairment is one of the most common complications in elderly surgical patients. Laser laryngeal surgery is a short procedure, but characterized by high risk of disastrous airway fire. So the recommended oxygen concentration is less than 30%. For elderly patients, because of preoperatively declined cardiovascular and lung function and cognitive function, there is a potential that intraoperative low oxygen concentration may lead to drop of arterial oxygen tension, decrease of brain oxygenation, and exacerbate brain function impairment. Intravenous anesthesia and inhalation anesthesia is two commonly used technique for general anesthesia. Consequently, we carry out this study to identify whether different classes of anesthetics can affect postoperative cognitive function in old patient undergoing laser laryngeal surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
Miller D, Lewis SR, Pritchard MW, Schofield-Robinson OJ, et al · · 2018 · cited 170× · PMID 30129968 · DOI 10.1002/14651858.cd012317.pub2
Verify or expand the search:
- PubMed search for NCT03194074
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other Eye & ENT Hospital of Fudan University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03194074 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Eye & ENT Hospital of Fudan University
- Last refreshed: 26 July 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03194074.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing