Who is sponsoring NCT00528515?

NCT00528515 is sponsored by Medical University of Gdansk.

What drugs are being tested in NCT00528515?

Interventions in NCT00528515: Diprivan (propofol), Astra-Zeneca, Suprane (desflurane), Baxter.

What condition does NCT00528515 study?

NCT00528515 studies Coronary Artery Disease.

Is NCT00528515 still recruiting?

NCT00528515 is currently completed. Last updated 15 May 2008.

Last reviewed 2008-05-15 · How we verify

NCT00528515

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Desflurane and Propofol Anesthesia for Off-Pump Coronary Artery Bypass Grafting Surgery

Completed Phase 4 Last updated 15 May 2008

What this trial tests

Phase 4 trial testing Diprivan (propofol), Astra-Zeneca in Coronary Artery Disease in 80 participants. Completed in 1 March 2008.

Timeline

1 February 2007

Primary endpoint
1 March 2008

1 March 2008

Quick facts

Lead sponsor	Medical University of Gdansk
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	80
Start date	1 February 2007
Primary completion	1 March 2008
Estimated completion	1 March 2008
Sites	1 location across Poland

Drugs / interventions tested

Diprivan (propofol), Astra-Zeneca — full drug profile →
Suprane (desflurane), Baxter — full drug profile →

Conditions studied

Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

Medical University of Gdansk

Who can join

Adults 18 to 75, any sex, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Markers of heart muscle injury and inflammation will be compared: troponin I, creatinine phosphokinase and its heart specific fraction, C-reactive protein.
Time frame: within the first 2. days after surgery.

Sponsor's own description

The purpose of this study is to prove if anesthesia maintained with the inhaled volatile anesthetic desflurane is superior to the intravenously applied propofol anesthesia in off-pump coronary artery bypass grafting (OP-CABG) surgery as measured by following parameters: 1. hemodynamic parameters during and after the operation, 2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital stay, 3. release of heart muscle injury markers in response to surgery and intraoperative ischaemia, 4. inflammatory response to the operation. We suspect that insufflation anesthesia with desflurane may be superior to intravenous anesthesia with propofol.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison of haemodynamics and myocardial injury markers under desflurane vs. propofol anaesthesia for off-pump coronary surgery. A prospective randomised trial.
Mroziński P, Lango R, Biedrzycka A, Kowalik MM, et al · · 2014 · cited 11× · PMID 24643920 · DOI 10.5603/ait.2014.0002

Verify or expand the search:

Other trials of Diprivan (propofol), Astra-Zeneca

Trials testing the same drug.

NCT06644573 — Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia · Phase 1 · not yet recruiting

Other recruiting trials for Coronary Artery Disease

Currently open trials in the same condition.

NCT07399002 — LONG NAGOMI™ PMCF STUDY · recruiting
NCT07420582 — Antegrade Autologous Blood Reinfusion After CPB · recruiting
NCT07493603 — A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease · Phase 1, PHASE2 · recruiting
NCT06535568 — Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO · NA · recruiting
NCT07286578 — A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Under · NA · recruiting

Other Medical University of Gdansk trials

Trials by the same sponsor.

NCT07521280 — State-Based Rehabilitation for Youth Athletes With Osgood-Schlatter or Sever-Related Apophyseal Pain · NA · not yet recruiting
NCT07446517 — Low-Level Laser Therapy for Osgood-Schlatter or Sever Pain in Youth Athletes · NA · recruiting
NCT07449585 — Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty · NA · not yet recruiting
NCT07397208 — Assessment of the Repeatability of Sublingual Microcirculation Function Measurements in Healthy Volunteers and Criticall · not yet recruiting
NCT07345403 — GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Ana · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00528515 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Gdansk
Last refreshed: 15 May 2008

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00528515.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing