NCT02322502

Emergence Times and Airway Reactions in General Laryngeal Mask Airway Anesthesia: a Randomized Multicenter Controlled Trial (ACC Baxter)

Completed Phase 3 Last updated 5 October 2016

What this trial tests

Phase 3 trial testing Desflurane in Anesthesia With Use of LMA (Laryngeal Mask Airway) in 352 participants. Completed in 1 February 2016.

Timeline

1 February 2015

Primary endpoint
1 February 2016

1 February 2016

Quick facts

Lead sponsor	RWTH Aachen University
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	352
Start date	1 February 2015
Primary completion	1 February 2016
Estimated completion	1 February 2016
Sites	4 locations across Germany

Drugs / interventions tested

• Desflurane (DESFLURANE) — full drug profile →
• Sevoflurane — full drug profile →
• propofol (Propofol) — full drug profile →

Conditions studied

• Anesthesia With Use of LMA (Laryngeal Mask Airway) — all drugs for Anesthesia With Use of LMA (Laryngeal Mask Airway) →

Sponsor

RWTH Aachen University

Who can join

Adults 18 to 75, any sex, with Anesthesia With Use of LMA (Laryngeal Mask Airway). Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• time of emergence from anesthesia
  Time frame: up to 15 minutes
  time of emergence from anesthesia defined as time between cessation of anesthesia until patient is able to state his/her date of birth on command

Sponsor's own description

The aim of this study is first to assess if desflurane is superior in order to achieve a faster emergence from anesthesia.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Emergence times and airway reactions during general anaesthesia with remifentanil and a laryngeal mask airway: A multicentre randomised controlled trial.
   Kowark A, Rossaint R, Pühringer F, Keszei AP, et al · · 2018 · cited 7× · PMID 29916859 · DOI 10.1097/eja.0000000000000852
2. Emergence times and airway reactions in general laryngeal mask airway anesthesia: study protocol for a randomized controlled trial.
   Stevanovic A, Rossaint R, Keszei AP, Fritz H, et al · · 2015 · cited 2× · PMID 26210907 · DOI 10.1186/s13063-015-0855-2