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SEVOFLURANE
Sevoflurane is a marketed anesthetic agent used for the induction and maintenance of general anesthesia, holding a significant position in the anesthetic market. Its key strength lies in its well-established use and safety profile, supported by a key composition patent expiring in 2028. The primary risk is the potential increase in competition as the patent expiration approaches, which could impact market share and revenue.
At a glance
| Generic name | SEVOFLURANE |
|---|---|
| Drug class | General Anesthetic [EPC] |
| Modality | Small molecule |
| Phase | FDA-approved |
| First approval | 1995 |
Approved indications
- Induction and maintenance of general anesthesia
Common side effects
- Nausea
- Vomiting
- Agitation
- Hypotension
- Cough Increased
- Somnolence
- Dizziness
- Laryngospasm
- Airway Obstruction
- Agitation
- Tachycardia
- Shivering
Serious adverse events
- Malignant Hyperthermia
- Seizures
- Cardiac Arrest
- QT Prolongation with Torsade de Pointe
- Diffuse Alveolar Hemorrhage
- Hepatic Dysfunction/Hepatitis
- Delirium
- Bradycardia in Down Syndrome Patients
- Bronchospasm
- Hypoxia
Drug interactions
- Epinephrine
- Calcium antagonists
- Verapamil
- Non-selective MAO-inhibitors
- Nitrous Oxide
- Neuromuscular Blocking Agents (nondepolarizing)
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Target-Controlled Infusion (TCI) vs Inhalational Anesthesia in Video-Assisted Thoracoscopic Surgery (VATS)
- Deep Versus Moderate Neuromuscular Blocking (NA)
- Low-flow Versus Minimal-flow Sevoflurane Anesthesia During Robot-assisted Laparoscopic Radical Prostatectomy (NA)
- Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy (NA)
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- Perioperative Hypothermia and Sevoflurane Consumption in Elderly Patients
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SEVOFLURANE CI brief — competitive landscape report
- SEVOFLURANE updates RSS · CI watch RSS