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NCT02191371
Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
NA trial testing propofol in Mechanical Ventilation Complication in 104 participants. Completed in 1 December 2014.
1 December 2014
Quick facts
| Lead sponsor | Seoul National University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 104 |
| Start date | 1 July 2014 |
| Primary completion | 1 December 2014 |
| Estimated completion | 1 December 2014 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- propofol (Propofol) — full drug profile →
- desflurane (DESFLURANE) — full drug profile →
Conditions studied
- Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
Sponsor
Seoul National University Hospital
Who can join
Adults 20 to 90, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
arterial partial pressure of oxygen
Time frame: 30 min after one-lung ventilation
Primary outcome is arterial partial pressure of oxygen 30 min after one-lung ventilation during thoracic surgery in propofol and desflurane groups.
Sponsor's own description
One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effect of desflurane-remifentanil vs. Propofol-remifentanil anesthesia on arterial oxygenation during one-lung ventilation for thoracoscopic surgery: a prospective randomized trial.
Cho YJ, Kim TK, Hong DM, Seo JH, et al · · 2017 · cited 22× · PMID 28100177 · DOI 10.1186/s12871-017-0302-x
Verify or expand the search:
- PubMed search for NCT02191371
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of propofol
Trials testing the same drug.
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- NCT06907823 — Comparison of Sevoflurane and Propofol on ANI · NA · not yet recruiting
- NCT06990763 — Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological · NA · not yet recruiting
- NCT06976996 — Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery · NA · active not recruiting
- NCT07285980 — Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain · NA · completed
Other recruiting trials for Mechanical Ventilation Complication
Currently open trials in the same condition.
- NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
- NCT07207772 — EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery · NA · recruiting
- NCT07182851 — Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units · recruiting
- NCT06575530 — Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients · Phase 4 · recruiting
- NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting
Other Seoul National University Hospital trials
Trials by the same sponsor.
- NCT07262944 — EOI Block in Otoplasty With Rib Cartilage Graft · NA · recruiting
- NCT07464210 — Nemtabrutinib, Bortezomib, and Rituximab for WM · Phase 2 · not yet recruiting
- NCT07550803 — Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery · NA · not yet recruiting
- NCT07522138 — Home-based Self-exercise in Patients With Parkinson's Disease: A Feasibility Study · NA · not yet recruiting
- NCT07476651 — Scout Dose of Resin Microspheres · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02191371 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Seoul National University Hospital
- Last refreshed: 12 October 2016
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02191371.
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