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NCT07285980: BBLP
Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain
NA trial testing propofol in Propofol Injection Pain in 180 participants. Completed in 31 July 2025.
31 July 2025
Quick facts
| Lead sponsor | Asma Ladib |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 180 |
| Start date | 1 March 2025 |
| Primary completion | 31 July 2025 |
| Estimated completion | 31 July 2025 |
| Sites | 1 location across Tunisia |
Drugs / interventions tested
- propofol (Propofol) — full drug profile →
- Lidocaine - Propofol Mixture — full drug profile →
- Lidocaine - Bier Block — full drug profile →
Conditions studied
- Propofol Injection Pain — all drugs for Propofol Injection Pain →
Sponsor
Asma Ladib — full company profile →
Who can join
18 and older, any sex, with Propofol Injection Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial was to evaluate methods to prevent pain on intravenous administration of propofol during induction of anesthesia. Propofol frequently causes a burning or painful sensation when injected into a peripheral vein. This randomized study compared three approaches in adult patients scheduled for elective surgery: propofol alone (control), propofol with 40 mg lidocaine mixed directly, and a brief intravenous lidocaine under venous occlusion (Bier block) using 40 mg for 2 minutes before propofol. The primary outcome was the incidence of pain on propofol injection measured with a 4-point verbal rating scale (0 = no pain to 3 = severe pain). Secondary outcomes included pain intensity, peri-induction hemodynamic parameters, and local injection-site adverse effects.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT07285980
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of propofol
Trials testing the same drug.
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- NCT06990763 — Network Pharmacology Was Applied to Explore the Mechanism of Remimazolam Applied in General Anesthesia for Gynecological · NA · not yet recruiting
- NCT06976996 — Efficacy of Esketamine Combined With Different General Anesthetics on Quality of Postoperative Recovery · NA · active not recruiting
- NCT06775366 — The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07285980 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Asma Ladib
- Last refreshed: 26 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07285980.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing