Mucolytic agent; antioxidant
This page covers all Mucolytic agent; antioxidant drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Glutathione synthesis; disulfide bonds in mucoproteins, Mucus glycoprotein synthesis, Glutathione synthesis pathway; reactive oxygen species (non-specific).
Targets
Glutathione synthesis; disulfide bonds in mucoproteins · Mucus glycoprotein synthesis · Glutathione synthesis pathway; reactive oxygen species (non-specific) · Beta-2 adrenergic receptor (albuterol); disulfide bonds in mucoproteins (N-acetylcysteine) · Glutathione synthesis pathway; free radicals; mucus proteins · Glutathione synthesis pathway; reactive oxygen species · Glutathione synthesis pathway; mucus disulfide bonds · Alpha-1 adrenergic receptors, beta-2 adrenergic receptors, osmotic gradient modulation · Disulfide bonds in mucoproteins; glutathione synthesis pathway · Glutathione synthesis pathway; free radicals and reactive oxygen species
Marketed (14)
- Acetylcysteine (NAC) · Clinica Universidad de Navarra, Universidad de Navarra · Respiratory; Toxicology; General Medicine
Acetylcysteine is a mucolytic agent that breaks disulfide bonds in mucoproteins, reducing mucus viscosity and facilitating clearance, while also serving as a precursor to glutathione for antioxidant protection. - Nebulized 3% sodium chloride solution · NYU Langone Health · Pulmonology/Respiratory
Nebulized hypertonic saline draws fluid into the airways through osmotic gradient, hydrating secretions and promoting mucus clearance. - Mucodyne · Metabolic
- Mucolox® alone · University of Alberta · Respiratory
Mucolox is a mucus-thinning agent that reduces mucus viscosity to improve clearance and airway function in patients with excessive or thick mucus production. - N-Acetyl Cysteine (NAC) · The Aurum Institute NPC · Respiratory, Toxicology, Nephrology, Hepatology
N-Acetyl Cysteine (NAC) replenishes intracellular glutathione, a major antioxidant, and provides a free thiol group that directly scavenges reactive oxygen species and electrophiles. - n-acetylcystine + albuterol · University of California, San Francisco · Respiratory
N-acetylcysteine reduces mucus viscosity by breaking disulfide bonds in mucoproteins, while albuterol bronchodilates airways via beta-2 adrenergic stimulation, together improving airway clearance and breathing. - N-acetylcystein · Assistance Publique - Hôpitaux de Paris · Respiratory; Toxicology; General supportive care
N-acetylcysteine (NAC) replenishes intracellular glutathione and acts as a free radical scavenger to reduce oxidative stress and cellular damage. - N-acetylcysteine · University of Turin, Italy · Respiratory, Toxicology, General Medicine
N-acetylcysteine replenishes intracellular glutathione, a major antioxidant, and directly scavenges reactive oxygen species and electrophiles. - N Acetylcysteine A · Department of Medical Services Ministry of Public Health of Thailand · Respiratory; Toxicology; General supportive care
N-acetylcysteine replenishes intracellular glutathione and acts as a mucolytic agent to reduce mucus viscosity and support antioxidant defenses. - Ambroxol Hydrochloride · National University of Malaysia · Respiratory
Ambroxol hydrochloride is a mucolytic agent that breaks down and reduces the viscosity of respiratory mucus, facilitating clearance and improving airway patency. - Acetylcysteine/Doxofylline · Neutec Ar-Ge San ve Tic A.Ş · Respiratory/Pulmonology
Acetylcysteine acts as a mucolytic agent to break down mucus, while doxofylline is a xanthine derivative that acts as a bronchodilator and anti-inflammatory agent. - Hypertonic saline and epinephrine · Le Bonheur Children's Hospital · Pulmonology / Pediatric respiratory disease
Hypertonic saline increases airway osmolarity to promote mucus clearance, while epinephrine causes vasoconstriction and reduces airway edema and mucus production. - N-acetylcysteine + PPI-amoxicillin-clarithromycin · National Taiwan University Hospital · Gastroenterology / Infectious Disease
This combination therapy eradicates Helicobacter pylori infection by using antibiotics to kill the bacteria while N-acetylcysteine reduces mucus viscosity and a PPI suppresses gastric acid to optimize antibiotic efficacy. - NAC · Otologic Pharmaceutics, Inc. · Otology / Respiratory / General
NAC (N-acetylcysteine) is a mucolytic and antioxidant agent that breaks down mucus viscosity and replenishes intracellular glutathione to reduce oxidative stress.
Phase 3 pipeline (9)
- Corticoids plus N Acetyl Cysteine · Centre Hospitalier Universitaire, Amiens · Respiratory/Pulmonary
Corticoids reduce inflammation and immune response while N-acetyl cysteine provides antioxidant support and mucolytic activity to protect lung tissue. - Oral N-Acetyl Cystein · Imam Khomeini Hospital · Respiratory
N-Acetyl Cysteine acts as an antioxidant and mucolytic agent by replenishing intracellular glutathione levels and breaking disulfide bonds in mucus. - IV N-Acetyl Cystein · Imam Khomeini Hospital · Critical Care / Respiratory / Toxicology
N-Acetyl Cysteine (NAC) replenishes intracellular glutathione and acts as a potent antioxidant to reduce oxidative stress and inflammation. - Ambroxol Hydrochloride (420mg) · University College, London · Respiratory
Ambroxol is a mucolytic agent that breaks down and reduces the viscosity of respiratory mucus, facilitating clearance from the airways. - Bromhexine and Spironolactone · Lomonosov Moscow State University Medical Research and Educational Center · Respiratory and Cardiovascular
Bromhexine acts as a mucolytic agent to thin respiratory secretions while spironolactone is a potassium-sparing diuretic and aldosterone antagonist. - IV N-acetylcysteine · Medical University of South Carolina · Critical Care / Toxicology / Respiratory
IV N-acetylcysteine replenishes intracellular glutathione and acts as a free radical scavenger to reduce oxidative stress and inflammation. - NAC + Bromhexine (BMX) · Universidade Federal do Ceara · Respiratory/Pulmonology
NAC and bromhexine work synergistically to reduce mucus viscosity and promote clearance while providing antioxidant and anti-inflammatory effects. - ambroxol BIH1526 · Sanofi · Respiratory
Ambroxol BIH1526 is a mucolytic agent that works by increasing the concentration of glutathione in the airways, which helps to break down and clear mucus. - Inhaled Reduced Glutathione · Serafino A. Marsico · Respiratory / Pulmonary
Inhaled reduced glutathione acts as an antioxidant and mucolytic agent that replenishes intracellular glutathione levels and reduces oxidative stress in the lungs.
Phase 1 pipeline (1)
- Acetylcysteine 2% solution · GlaxoSmithKline · Respiratory
N-acetylcysteine is a mucolytic agent that works by breaking disulfide bonds in mucus
Patent intelligence
- mucolytic patent landscape — aggregated cliff calendar, attackable patents, originator estates