What are Fluoroquinolone antibiotic drugs?

Fluoroquinolone antibiotic drugs are pharmacologic agents that share a common mechanism (typically targeting DNA gyrase; Topoisomerase IV). 23 are currently marketed, with 16 more in clinical development.

What are the marketed Fluoroquinolone antibiotic drugs?

Marketed Fluoroquinolone antibiotic drugs include Levofloxacin film-coated tablet, gatifloxacin ophthalmic solution 0.3%, Ofloxacin 0.3%, Moxifloxacin HCl 0.5%, Cipro, Placebo Drink + Moxifloxacin Capsule.

Fluoroquinolone antibiotic

23 marketed 14 in Phase 3 2 in Phase 2

This page covers all Fluoroquinolone antibiotic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting DNA gyrase; Topoisomerase IV, DNA gyrase, Topoisomerase IV, Bacterial DNA gyrase and topoisomerase IV.

Targets

DNA gyrase; Topoisomerase IV · DNA gyrase, Topoisomerase IV · Bacterial DNA gyrase and topoisomerase IV · DNA topoisomerase II, DNA gyrase subunit A, DNA gyrase subunit A · DNA gyrase, topoisomerase IV · Bacterial DNA gyrase; topoisomerase IV · Bacterial DNA gyrase (topoisomerase II) and topoisomerase IV · DNA gyrase and topoisomerase IV

Marketed (23)

Levofloxacin film-coated tablet · Mackay Memorial Hospital · Infectious Disease
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
gatifloxacin ophthalmic solution 0.3% · Allergan · Ophthalmology / Infectious Disease
Gatifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
Ofloxacin 0.3% · Indiana University School of Medicine · Infectious Disease / Ophthalmology
Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Moxifloxacin HCl 0.5% · Carolina Eyecare Physicians, LLC · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in bacteria.
Cipro · Bayer AG · Neuroscience
Placebo Drink + Moxifloxacin Capsule · University of the Pacific · Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Moxifloxacin 0.5% ophthalmic solution · Johns Hopkins University · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and causing bacterial cell death.
Moxifloxacin (M) · Global Alliance for TB Drug Development · Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Moxifloxacin (Avelox) · Connect Biopharma Australia Pty Ltd · Infectious Disease
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Ciprofloxacin 0.3% · Indiana University School of Medicine · Infectious Disease / Ophthalmology
Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
levofloxacin-based sequential therapy · National Taiwan University Hospital · Infectious Disease; Gastroenterology
Levofloxacin-based sequential therapy uses a fluoroquinolone antibiotic in a multi-step treatment regimen to eradicate bacterial infections, particularly Helicobacter pylori in peptic ulcer disease.
Oral norfloxacin · Hospital Clinic of Barcelona · Infectious Disease
Norfloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Third generation fluoroquinolone · University of Roma La Sapienza · Infectious Disease
Third-generation fluoroquinolones inhibit bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible microorganisms.
moxifloxacin 0.5% eye drops · Allergan · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
Vigamox Eye Drops · Merck Sharp & Dohme LLC · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Levofloxacin intravenous solution · Mackay Memorial Hospital · Infectious Disease
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Renamezin capsule · Daewon Pharmaceutical Co., Ltd. · Infectious Disease
Renamezin is an antibiotic that inhibits bacterial protein synthesis by binding to the bacterial ribosome.
Moxifloxacin (Topical) · University of California, San Francisco · Infectious Disease / Ophthalmology
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible microorganisms.
moxifloxacin 0.5% HCI ophthalmic solution · Allergan · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and causing bacterial cell death.
Moxifloxacin ophthalmic solution 0.5% · Ophthalmic Consultants of Boston · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
Moxifloxacin Injectable Product · Fundacion Clinic per a la Recerca Biomédica · Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Intracameral Moxifloxacin 0.1% · Suzan A Rattan · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in bacteria.
IV levofloxacin · Pfizer · Infectious Disease
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible microorganisms.

Phase 3 pipeline (14)

nebulized levofloxacin · University of Rochester · Infectious diseases
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
Levofloxacin oral tablets · GlaxoSmithKline · Infectious Disease
Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
OTO-201 (ciprofloxacin) · Otonomy, Inc. · Otology / Infectious Disease
OTO-201 is a sustained-release formulation of ciprofloxacin, a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV to kill bacteria in the middle ear.
Ciprofloxacin single dose · Bayer · Infectious Disease
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
standard adjuvant chemotherapy plus moxifloxacin · Sun Yat-sen University · Infectious Diseases
Moxifloxacin is a broad-spectrum antibiotic that inhibits bacterial DNA replication by binding to the bacterial DNA gyrase and topoisomerase IV.
Gatifloxacin 0.5% eye drops · Allergan · Ophthalmology / Infectious Disease
Gatifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
Gatifloxacin combined regimen · Institut de Recherche pour le Developpement · Infectious Disease
Gatifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible microorganisms.
Ciprofloxacin triple dose · Bayer · Infectious Disease
Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Ciprofloxacin DPI (BAYQ3939) · Bayer · Infectious Disease
Ciprofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Ciprofloxacin (BAYO9867) · Bayer · Infectious Disease
Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
Moxifloxacin Hydrochloride, Ophthalmic · Laboratorios Sophia S.A de C.V. · Ophthalmology / Infectious Disease
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible microorganisms.
Sitafloxacin (S) · Shenzhen Third People's Hospital · Infectious diseases
Sitafloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
Gemifloxacin-based triple therapy · Samsung Medical Center · Infectious Disease
Gemifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription in susceptible bacteria.
CXA-201 · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) · Infectious Disease
CXA-201 is a novel antibiotic that inhibits bacterial protein synthesis by targeting the ribosome.

Phase 2 pipeline (2)

Levofloxacin only · Innocoll · Infectious Disease
Inhibits DNA gyrase and topoisomerase IV
Ciprofloxacin 0.3% ophthalmic solution · Allergan · Ophthalmology
Ciprofloxacin 0.3% ophthalmic solution works by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication and transcription.