DNA gyrase and topoisomerase IV — Drug Target

All drugs that target DNA gyrase and topoisomerase IV — marketed and clinical-stage. Includes 6 drug classes acting on this target.

Drug classes

Fluoroquinolone · fluoroquinolone antibiotic · fluoroquinolone · Quinolone antibiotic · Bacterial topoisomerase inhibitor · Fluoroquinolone antibiotic

Marketed (2)

• Gatifloxacin 0.3% · Innovative Medical · Fluoroquinolone · Infectious Disease
• Experimental: Active "I-Reconstruction" Therapy · International Association Psychosomatics And Health Therapy · Fluoroquinolone · Infectious Disease
  Ofloxacin ophthalmic solution is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, leading to bacterial cell death.

Phase 3 pipeline (6)

• nebulized levofloxacin · University of Rochester · fluoroquinolone antibiotic · Infectious diseases
  Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription.
• Moxifloxacin or Levofloxacin · UMC Utrecht · fluoroquinolone · Infectious Diseases
  Moxifloxacin and Levofloxacin are broad-spectrum antibiotics that inhibit DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication.
• ozenoxacin 1% cream · Ferrer Internacional S.A. · Quinolone antibiotic · Dermatology
  Ozenoxacin is a quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
• Sitafloxacin (S) · Shenzhen Third People's Hospital · fluoroquinolone antibiotic · Infectious diseases
  Sitafloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
• standard adjuvant chemotherapy plus moxifloxacin · Sun Yat-sen University · fluoroquinolone antibiotic · Infectious Diseases
  Moxifloxacin is a broad-spectrum antibiotic that inhibits bacterial DNA replication by binding to the bacterial DNA gyrase and topoisomerase IV.
• Placebo matching gepotidacin · GlaxoSmithKline · Bacterial topoisomerase inhibitor · Infectious Disease
  Gepotidacin is a novel bacterial topoisomerase inhibitor that prevents bacterial DNA replication and transcription by targeting DNA gyrase and topoisomerase IV.

Phase 2 pipeline (3)

• Gatifloxacin 0.3% ophthalmic solution · Allergan · Quinolone antibiotic · Infectious Disease
  Quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
• Ciprofloxacin 0.3% ophthalmic solution · Allergan · fluoroquinolone antibiotic · Ophthalmology
  Ciprofloxacin 0.3% ophthalmic solution works by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication and transcription.
• Levofloxacin only · Innocoll · Fluoroquinolone antibiotic · Infectious Disease
  Inhibits DNA gyrase and topoisomerase IV