What are calcium channel blocker drugs?

calcium channel blocker drugs are pharmacologic agents that share a common mechanism (typically targeting L-type calcium channels). 9 are currently marketed, with 17 more in clinical development.

What are the marketed calcium channel blocker drugs?

Marketed calcium channel blocker drugs include DHP, Verapamil Hydrochloride, NICARDIPINE HYDROCHLORIDE, Treatment T, Standard medication for variant angina, Treatment R.

calcium channel blocker

9 marketed 7 in Phase 3 10 in Phase 2

This page covers all calcium channel blocker drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting L-type calcium channels, L-type calcium channels (slow channels), Calcium ion channels.

Targets

L-type calcium channels · L-type calcium channels (slow channels) · Calcium ion channels · L-type voltage-gated calcium channel · Voltage-dependent L-type calcium channel subunit alpha-1C · Calcium channels · L-type calcium channel

Marketed (9)

DHP · Centro de Investigacao em Saude de Manhica · Cardiovascular
DHP is a dihydropyridine calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
Verapamil Hydrochloride · Pfizer Inc. · Cardiovascular
Calcium ion influx inhibitor that modulates ionic calcium across cell membranes of arterial smooth muscle and myocardial cells.
NICARDIPINE HYDROCHLORIDE · Cardiovascular
Nicardipine blocks calcium ion influx into vascular smooth muscle, causing relaxation with minimal effect on cardiac muscle.
Treatment T · Boryung Pharmaceutical Co., Ltd · Cardiovascular
Treatment T is a calcium channel blocker that works by inhibiting the influx of calcium ions into cardiac and vascular smooth muscle cells.
Standard medication for variant angina · Seoul National University Hospital · Cardiovascular
Calcium channel blockers relax coronary artery smooth muscle to prevent vasospasm and improve blood flow in variant angina.
Treatment R · Boryung Pharmaceutical Co., Ltd · Cardiovascular
Treatment R is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
Smilon® · Nang Kuang Pharmaceutical Co., Ltd. · Cardiovascular
Smilon is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
Isoptin · Cardiovascular
Calcium Channel Blockers · Hospital de Clinicas de Porto Alegre · Cardiovascular
Calcium channel blockers inhibit the influx of calcium ions into vascular smooth muscle and cardiac cells, causing vasodilation and reduced cardiac contractility.

Phase 3 pipeline (7)

mg sulphate · Ain Shams University · Cardiovascular, Obstetrics
Magnesium sulphate works by blocking calcium channels in the body, which helps to relax muscles and improve blood flow.
Placebo of Nifedipine · Assistance Publique - Hôpitaux de Paris · Cardiovascular
Nifedipine is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
intrathecal magnesium sulfate · University Hospital, Clermont-Ferrand · Pain management
Magnesium sulfate acts as a calcium channel blocker, reducing neuronal excitability and inhibiting neurotransmitter release.
Group C: CsAm · Poitiers University Hospital · Cardiovascular
CsAm is a calcium channel blocker that inhibits the influx of calcium ions into cardiac and smooth muscle cells.
Diltiazem Hydrochloride 2% Cream · Ventrus Biosciences, Inc · Dermatology / Pain Management
Diltiazem is a calcium channel blocker that reduces smooth muscle contraction and improves blood flow when applied topically to affected tissues.
Treatment with nifedipine · Laboratorios Richmond S.A.C.I.F. · Cardiovascular
Nifedipine works by inhibiting the L-type calcium channels in smooth muscle cells, leading to vasodilation and a decrease in blood pressure.
Diltiazem hydrochloride 4% cream · S.L.A. Pharma AG · Dermatology / Pain Management
Diltiazem is a calcium channel blocker that reduces smooth muscle contraction and improves blood flow when applied topically to affected tissues.

Phase 2 pipeline (10)

BP1.3656 intermediate dose · Bioprojet · Cardiovascular
BP1.3656 intermediate dose is a medication that helps to lower blood pressure by affecting the body's ability to regulate blood vessel constriction.
Levoamlodipine Maleate Table · Hasten Biopharmaceutical Co., Ltd. · Cardiovascular
Calcium channel blocker
CM4620-IE · CalciMedica, Inc. · Cardiovascular
CM4620-IE is a small molecule that targets the calcium channel.
Approved Hypertrophic Cardiomyopathy drug treatments · Bristol-Myers Squibb · Cardiovascular
Calcium channel blocker
Amlodipine-FA tablet,high dose group · Shenzhen Ausa Pharmed Co.,Ltd · Cardiovascular
Amlodipine-FA tablet works by inhibiting the L-type calcium channels in smooth muscle cells, leading to vasodilation and reduced blood pressure.
Amlodipine-FA tablet,low dose group · Shenzhen Ausa Pharmed Co.,Ltd · Cardiovascular
Amlodipine-FA is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
Amlodipine low · Addpharma Inc. · Cardiovascular
Amlodipine is a calcium channel blocker that works by relaxing blood vessels and reducing blood pressure.
Amlodipine High · Handok Inc. · Cardiovascular
Calcium channel blocker
CCB use · GlaxoSmithKline · Cardiovascular
CCBs work by inhibiting the L-type calcium channels in the heart and vascular smooth muscle, leading to vasodilation and reduced cardiac workload.
Benidipine Hydrochloride · The Society of Prevention and Awareness of Cardiovascular Diseases · Cardiovascular
Calcium channel blocker