Last reviewed 2026-04-23 · How we verify

Amlodipine High

Calcium channel blocker

Calcium channel blocker Used for Hypertension, Angina.

At a glance

Mechanism of action

Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle.

Approved indications

• Hypertension
• Angina

Common side effects

• Edema
• Dizziness
• Headache

Key clinical trials

• Antihypertensive Drug Selection Based on Hemodynamic Phenotypes (PHASE4)
• Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2) (PHASE2)
• Exploring the Impact of Nephropathy Formula No. 1 on Chronic Kidney Disease Patients (EARLY_PHASE1)
• The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans (PHASE4)
• Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study) (PHASE2)
• A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial) (PHASE3)
• Calcium Channel Blocker Amlodipine for Endometrial Cancer Therapy (PHASE2)
• Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Amlodipine High CI brief — competitive landscape report
• Amlodipine High updates RSS · CI watch RSS
• Handok Inc. portfolio CI