L-type voltage-gated calcium channel — Drug Target

All drugs that target L-type voltage-gated calcium channel — marketed and clinical-stage. Includes 4 drug classes acting on this target.

Drug classes

Calcium channel blocker (dihydropyridine) · Calcium channel blocker · Dihydropyridine calcium channel blocker · Non-dihydropyridine calcium channel blocker

Marketed (15)

• Nifedipine GITS · Peking University First Hospital · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Nifedipine GITS is a long-acting calcium channel blocker that reduces calcium influx into vascular smooth muscle cells, causing vasodilation and lowering blood pressure.
• Standard medication for variant angina · Seoul National University Hospital · Calcium channel blocker · Cardiovascular
  Calcium channel blockers relax coronary artery smooth muscle to prevent vasospasm and improve blood flow in variant angina.
• Levamlodipine besylate · Jiangsu Simcere Pharmaceutical Co., Ltd. · Dihydropyridine calcium channel blocker · Cardiovascular
  Levamlodipine besylate is the active L-enantiomer of amlodipine that blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reducing blood pressure.
• Amlodipine+standard antihypertensive therapy · Beijing Tiantan Hospital · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine blocks L-type calcium channels in vascular smooth muscle to reduce blood pressure, used here as part of combination antihypertensive therapy.
• nifedipine CR tablets (Adalat) · Shanghai Shyndec Pharmaceutical Co., Ltd. · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Nifedipine is a calcium channel blocker that inhibits calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and reduced blood pressure.
• nicardipine intravenous · Haseki Training and Research Hospital · Dihydropyridine calcium channel blocker · Cardiovascular
  Nicardipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reducing blood pressure.
• Adalat (Nifedipine, BAYA1040) · Bayer · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Nifedipine blocks calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and reduced blood pressure.
• Amlodipine+intensive antihypertensive therapy · Beijing Tiantan Hospital · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine blocks L-type calcium channels in vascular smooth muscle to reduce blood pressure, often combined with other antihypertensive agents for enhanced efficacy.
• Lacidipine & Amlodipine · Korea University Guro Hospital · Dihydropyridine calcium channel blocker · Cardiovascular
  Lacidipine and amlodipine are dihydropyridine calcium channel blockers that inhibit L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reducing blood pressure.
• Amlodipine 5 or 10 mg(oral) · GlaxoSmithKline · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine blocks calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reduced blood pressure.
• Amlodipine (Norvasc) · Bayer · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine blocks calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reduced blood pressure.
• Diltiazem Injectable Product · Virginia Commonwealth University · Non-dihydropyridine calcium channel blocker · Cardiovascular
  Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits calcium influx into cardiac and vascular smooth muscle cells, reducing heart rate and blood pressure.
• nifedipine controlled release tablets · Guangzhou First People's Hospital · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Nifedipine is a calcium channel blocker that reduces calcium influx into vascular smooth muscle and cardiac cells, causing vasodilation and decreased blood pressure.
• Calcium Channel Blockers · Hospital de Clinicas de Porto Alegre · Calcium channel blocker · Cardiovascular
  Calcium channel blockers inhibit the influx of calcium ions into vascular smooth muscle and cardiac cells, causing vasodilation and reduced cardiac contractility.
• Amlodipine placebos · Shenzhen Ausa Pharmed Co.,Ltd · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine is a calcium channel blocker that relaxes blood vessels and reduces heart workload to lower blood pressure.

Phase 3 pipeline (6)

• Comparator: amlodipine besylate · Organon and Co · Calcium channel blocker (dihydropyridine) · Cardiovascular
  Amlodipine besylate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by inhibiting calcium influx into vascular smooth muscle cells.
• Intravenous Diltiazem · Oman Medical Speciality Board · Non-dihydropyridine calcium channel blocker · Cardiovascular
  Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits calcium influx into cardiac and vascular smooth muscle cells, reducing heart rate and blood pressure.
• S-amlodipine gentisate · SK Chemicals Co., Ltd. · Calcium channel blocker (dihydropyridine) · Cardiovascular
  S-amlodipine gentisate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by blocking L-type calcium channels in vascular smooth muscle.
• Ncardipine Hydrochloride Injection · Nanjing Yoko Biomedical Co., Ltd. · Dihydropyridine calcium channel blocker · Cardiovascular
  Nicardipine hydrochloride is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reducing blood pressure.
• Nifedipine cream topical application · Western Galilee Hospital-Nahariya · Calcium channel blocker (dihydropyridine) · Cardiovascular / Dermatology
  Nifedipine is a calcium channel blocker that relaxes vascular smooth muscle and improves blood flow when applied topically to affected tissues.
• Nimodipine group · University Hospital Hradec Kralove · Dihydropyridine calcium channel blocker · Neurology / Cardiovascular
  Nimodipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation and improved cerebral blood flow.