Dihydropyridine calcium channel blocker

This page covers all Dihydropyridine calcium channel blocker drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting L-type voltage-gated calcium channel, L-type calcium channel, AV nodal conduction (multiple targets depending on agent: beta-1 adrenergic receptors, L-type calcium channels, or adenosine receptors).

Targets

L-type voltage-gated calcium channel · L-type calcium channel · AV nodal conduction (multiple targets depending on agent: beta-1 adrenergic receptors, L-type calcium channels, or adenosine receptors) · HMG-CoA reductase; L-type calcium channels · Voltage-dependent T-type calcium channel subunit alpha-1H · Voltage-dependent L-type calcium channel subunit alpha-1C · Voltage-dependent L-type calcium channel subunit alpha-1D · Voltage-dependent L-type calcium channel subunit alpha-1F · 5-HT1A receptor; L-type calcium channel · Mineralocorticoid receptor (eplerenone); L-type voltage-gated calcium channel (amlodipine)

Marketed (21)

• Levamlodipine besylate · Jiangsu Simcere Pharmaceutical Co., Ltd. · Cardiovascular
  Levamlodipine besylate is the active L-enantiomer of amlodipine that blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reducing blood pressure.
• Amlodipine camsylate · Organon and Co · Cardiovascular
  Amlodipine camsylate blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, reducing calcium influx and causing vasodilation and decreased blood pressure.
• Cleviprex® · CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. · Cardiovascular
  Cleviprex is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation and reducing blood pressure.
• nicardipine intravenous · Haseki Training and Research Hospital · Cardiovascular
  Nicardipine is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reducing blood pressure.
• Rate-control therapy · Our Lady of the Lake Hospital · Cardiovascular
  Rate-control therapy slows the ventricular response rate in atrial fibrillation by reducing conduction through the atrioventricular node.
• statin, amlodipine · Gachon University Gil Medical Center · Cardiovascular
  This is a fixed-dose combination of a statin (HMG-CoA reductase inhibitor) and amlodipine (calcium channel blocker) that lowers cholesterol and reduces blood pressure simultaneously.
• Nifedipine (Adalat, BAYA1040) · Bayer · Cardiovascular
  Nifedipine blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, reducing calcium influx and causing vasodilation and decreased cardiac contractility.
• Caduet · Pfizer Inc. · Metabolic
  Calcium channel antagonist inhibiting transmembrane calcium influx into vascular and cardiac muscle.
• Plendil · AstraZeneca · Cardiovascular
  Plendil works by blocking calcium channels in blood vessel walls, causing them to relax and widen, which lowers blood pressure.
• Diltiazem treated group · Seoul National University Hospital · Cardiovascular
  Diltiazem blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx and decreasing heart rate and blood pressure.
• Procardia · Pfizer · Metabolic
• Procardia · Pfizer · Metabolic
• Cleviprex · Chiesi · Cardiovascular
  Cleviprex works by blocking calcium channels in blood vessel walls, causing them to relax and lower blood pressure.
• Dynacirc · Smithkline Beecham · Cardiovascular
• Cardene · Hikma Intl Pharms · Cardiovascular
  Cardene works by blocking calcium channels in the heart and blood vessels, which helps to relax and widen blood vessels, reducing blood pressure and heart workload.
• Nimotop · Neuroscience
• Sular · Azurity · Cardiovascular
  Sular works by blocking calcium channels in blood vessel walls, which relaxes the blood vessels and lowers blood pressure.
• Tandospirone + Amlodipine · Chongqing Medical University · Psychiatry/Neurology; Cardiovascular
  Tandospirone acts as a 5-HT1A receptor agonist for anxiety, while amlodipine is a calcium channel blocker for hypertension and angina.
• Diltiazem Injectable Product · Virginia Commonwealth University · Cardiovascular
  Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits calcium influx into cardiac and vascular smooth muscle cells, reducing heart rate and blood pressure.
• Eplerenone vs Amlodipine · Brigham and Women's Hospital · Cardiovascular
  This is a comparison of two marketed cardiovascular drugs: eplerenone, a selective aldosterone antagonist, and amlodipine, a calcium channel blocker, each working through different pathways to lower blood pressure.
• Lacidipine & Amlodipine · Korea University Guro Hospital · Cardiovascular
  Lacidipine and amlodipine are dihydropyridine calcium channel blockers that inhibit L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reducing blood pressure.

Phase 3 pipeline (3)

• Intravenous Diltiazem · Oman Medical Speciality Board · Cardiovascular
  Diltiazem is a non-dihydropyridine calcium channel blocker that inhibits calcium influx into cardiac and vascular smooth muscle cells, reducing heart rate and blood pressure.
• Nimodipine group · University Hospital Hradec Kralove · Neurology / Cardiovascular
  Nimodipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation and improved cerebral blood flow.
• Ncardipine Hydrochloride Injection · Nanjing Yoko Biomedical Co., Ltd. · Cardiovascular
  Nicardipine hydrochloride is a dihydropyridine calcium channel blocker that inhibits calcium influx into vascular smooth muscle cells, causing vasodilation and reducing blood pressure.

Patent intelligence

• dihydropyridine calcium channel blocker patent landscape — aggregated cliff calendar, attackable patents, originator estates