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S-amlodipine gentisate
S-amlodipine gentisate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by blocking L-type calcium channels in vascular smooth muscle.
S-amlodipine gentisate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by blocking L-type calcium channels in vascular smooth muscle. Used for Hypertension.
At a glance
| Generic name | S-amlodipine gentisate |
|---|---|
| Sponsor | SK Chemicals Co., Ltd. |
| Drug class | Calcium channel blocker (dihydropyridine) |
| Target | L-type voltage-gated calcium channel |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
S-amlodipine is the active S-enantiomer of amlodipine, a dihydropyridine calcium antagonist. The gentisate salt formulation may improve bioavailability or tolerability. By inhibiting calcium influx into vascular smooth muscle cells, it causes vasodilation and reduces peripheral vascular resistance, thereby lowering blood pressure.
Approved indications
- Hypertension
Common side effects
- Peripheral edema
- Headache
- Flushing
- Dizziness
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- S-amlodipine gentisate CI brief — competitive landscape report
- S-amlodipine gentisate updates RSS · CI watch RSS
- SK Chemicals Co., Ltd. portfolio CI