{"id":"s-amlodipine-gentisate","safety":{"commonSideEffects":[{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Dizziness"}]},"_chembl":{"chemblId":"CHEMBL1200402","moleculeType":"Small molecule","molecularWeight":"567.06"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"S-amlodipine is the active S-enantiomer of amlodipine, a dihydropyridine calcium antagonist. The gentisate salt formulation may improve bioavailability or tolerability. By inhibiting calcium influx into vascular smooth muscle cells, it causes vasodilation and reduces peripheral vascular resistance, thereby lowering blood pressure.","oneSentence":"S-amlodipine gentisate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by blocking L-type calcium channels in vascular smooth muscle.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:33:01.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"}]},"trialDetails":[{"nctId":"NCT00289406","phase":"PHASE3","title":"Efficacy and Safety Study of S-Amlodipine Gentisate Compared to Amlodipine Besylate to Treat Mild-to-Moderate Hypertension","status":"COMPLETED","sponsor":"SK Chemicals Co., Ltd.","startDate":"2006-01","conditions":"Hypertension","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"S-amlodipine gentisate","genericName":"S-amlodipine gentisate","companyName":"SK Chemicals Co., Ltd.","companyId":"sk-chemicals-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"S-amlodipine gentisate is a calcium channel blocker that relaxes blood vessels and reduces blood pressure by blocking L-type calcium channels in vascular smooth muscle. Used for Hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}