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Diltiazem hydrochloride 4% cream
Diltiazem hydrochloride 4% cream is a Calcium channel blocker Small molecule drug developed by S.L.A. Pharma AG. It is currently in Phase 3 development for Anal fissure pain relief (topical application).
Diltiazem is a calcium channel blocker that reduces smooth muscle contraction and improves blood flow when applied topically to affected tissues.
Diltiazem is a calcium channel blocker that reduces smooth muscle contraction and improves blood flow when applied topically to affected tissues. Used for Anal fissure pain relief (topical application).
At a glance
| Generic name | Diltiazem hydrochloride 4% cream |
|---|---|
| Sponsor | S.L.A. Pharma AG |
| Drug class | Calcium channel blocker |
| Target | L-type calcium channels |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Pain Management |
| Phase | Phase 3 |
Mechanism of action
Diltiazem inhibits the influx of calcium ions into vascular and cardiac smooth muscle cells, leading to vasodilation and reduced vasoconstriction. When formulated as a 4% cream for topical application, it is used to relieve pain and promote healing in localized conditions by improving microvascular blood flow and reducing smooth muscle spasm in the affected area.
Approved indications
- Anal fissure pain relief (topical application)
Common side effects
- Headache
- Local irritation or burning at application site
- Pruritus
Key clinical trials
- Topical Analgesia Post-Haemorrhoidectomy (PHASE2, PHASE3)
- Diltiazem Hydrochloride Cream for Anal Fissure (PHASE3)
- Study to Evaluate the Interaction Potential of Clarithromycin XL on Diltiazem Hydrochloride Cream 2% in Healthy Subjects (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diltiazem hydrochloride 4% cream CI brief — competitive landscape report
- Diltiazem hydrochloride 4% cream updates RSS · CI watch RSS
- S.L.A. Pharma AG portfolio CI
Frequently asked questions about Diltiazem hydrochloride 4% cream
What is Diltiazem hydrochloride 4% cream?
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Related
- Drug class: All Calcium channel blocker drugs
- Target: All drugs targeting L-type calcium channels
- Manufacturer: S.L.A. Pharma AG — full pipeline
- Therapeutic area: All drugs in Dermatology / Pain Management
- Indication: Drugs for Anal fissure pain relief (topical application)
- Compare: Diltiazem hydrochloride 4% cream vs similar drugs
- Pricing: Diltiazem hydrochloride 4% cream cost, discount & access