Last reviewed 2026-04-23 · How we verify

intrathecal magnesium sulfate

Magnesium sulfate acts as a calcium channel blocker, reducing neuronal excitability and inhibiting neurotransmitter release.

Magnesium sulfate acts as a calcium channel blocker, reducing neuronal excitability and inhibiting neurotransmitter release. Used for Acute postoperative pain, Status epilepticus.

At a glance

Mechanism of action

By blocking calcium channels, magnesium sulfate decreases the release of excitatory neurotransmitters, leading to a reduction in neuronal excitability. This mechanism is thought to contribute to its analgesic and anticonvulsant effects.

Approved indications

• Acute postoperative pain
• Status epilepticus

Common side effects

• Respiratory depression
• Hypotension
• Respiratory arrest

Key clinical trials

• Comparison Between Intrathecal Magnesium Sulphate & Dexmedetomidine in DHS (PHASE3)
• Comparison of Magnesium Sulphate vs Tramadol as Adjuvants in Intrathecal Bupivacaine for Postoperative Pain in TURP Patients (PHASE4)
• Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl As Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries (PHASE4)
• Intravenous Tramadol and Magnesium Sulphate for Prevention of Shivering (PHASE4)
• Effect of Intrathecal Magnesium Sulfate Versus Intravenous Magnesium Sulfate on Postoperative Pain After Abdominal Hysterectomy (PHASE2)
• The Effect of Intrathecal Magnesium Sulfate on Shivering (NA)
• the Use of Magnesium Sulfate for Prevention of Postspinal Shivering (PHASE4)
• Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors (NA)

Primary sources

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