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CCB use
CCBs work by inhibiting the L-type calcium channels in the heart and vascular smooth muscle, leading to vasodilation and reduced cardiac workload.
CCBs work by inhibiting the L-type calcium channels in the heart and vascular smooth muscle, leading to vasodilation and reduced cardiac workload. Used for Hypertension, Angina pectoris.
At a glance
| Generic name | CCB use |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Calcium channel blocker |
| Target | L-type calcium channels |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
This results in decreased peripheral resistance, reduced blood pressure, and a decrease in cardiac workload, which can help alleviate symptoms of hypertension and angina. CCBs can also have a negative inotropic effect, which can be beneficial in certain cardiac conditions.
Approved indications
- Hypertension
- Angina pectoris
Common side effects
- Edema
- Dizziness
- Headache
Key clinical trials
- Optimal Blood Pressure for the prevenTIon of Major vAscuLar Events in Patients With DIABETES Mellitus (OPTIMAL-DIABETES) (NA)
- De-Adoption of Beta-Blockers in Patients With Stable Ischemic Heart Disease (PHASE4)
- Focusing on the Menopausal Transition to Improve Mid-Life Women's Health (PHASE2, PHASE3)
- Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation (NA)
- Catheter Ablation Versus Anti-arrhythmic Drugs for Premature Ventricular Complexes (NA)
- Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage (PHASE4)
- Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication (NA)
- Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- CCB use CI brief — competitive landscape report
- CCB use updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI