Antifibrinolytic agent

This page covers all Antifibrinolytic agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Plasminogen / Plasmin, Plasminogen lysine binding sites; fibrin, Plasminogen.

Targets

Plasminogen / Plasmin · Plasminogen lysine binding sites; fibrin · Plasminogen · Plasmin, kallikrein, plasminogen activators

Marketed (18)

• tranexamic acid Oral-Short Arm · Rush University Medical Center · Hematology
  Tranexamic acid inhibits the conversion of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.
• Tranexamic Acid plus standard of care · Pfizer · Hematology / Surgery / Trauma
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding and promoting clot stability.
• Tranexamic Acid (TXA) · NYU Langone Health · Hematology / Hemostasis
  Tranexamic acid inhibits the breakdown of blood clots by blocking plasminogen activation, thereby reducing fibrinolysis and promoting clot stability.
• Tranexamic Acid / Sodium chloride · University Hospital, Bordeaux · Hematology / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding and promoting clot stability.
• Tranexamic acid intravenous administration · Dr. Lutfi Kirdar Kartal Training and Research Hospital · Hematology / Hemostasis
  Tranexamic acid inhibits the activation of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.
• Cyklokapron · Pfizer Inc. · Rare Disease
  Tranexamic acid occupies lysine receptor binding sites on plasmin, preventing fibrin dissolution.
• Tranexamic acid + Standard of Care · Pfizer · Hematology / Surgery / Trauma
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, reducing blood loss in surgical and trauma settings when combined with standard care.
• Tranexamic Acid (IV) · Samsung Medical Center · Hematology / Hemostasis
  Tranexamic acid inhibits the activation of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.
• Tranexamic Acid Pill · Henry Ford Health System · Hematology
  Tranexamic acid inhibits the breakdown of blood clots by blocking plasminogen activation, thereby reducing fibrinolysis.
• Trasylol · Bayer · Hematology
• Topical tranexamic acid · Aswan University Hospital · Dermatology
  Topical tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, reducing bleeding and promoting hemostasis at the site of application.
• aprotonin; epsilon aminocaproic acid · University of Rochester · Cardiovascular / Surgery
  This combination inhibits fibrinolysis by blocking plasmin-mediated clot breakdown, thereby reducing bleeding during and after surgery.
• Tranexamic Acid Injectable Product · The University of Texas Health Science Center at San Antonio · Hematology / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding.
• Tranexamic Acid Irrigation · University of Wisconsin, Madison · Surgery / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding during surgical procedures when applied as a local irrigation.
• IV TXA · Massachusetts General Hospital · Hematology / Hemostasis
  IV TXA (tranexamic acid) inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding.
• Tranexamic Acid Injectable Solution · Mount Sinai Hospital, Canada · Hematology / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding.
• Tranexamic Acid Dosage 1 · Chinese Academy of Medical Sciences, Fuwai Hospital · Hematology / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding.
• Tranexamic Acid (Topical) · Total Definer Research Group · Dermatology / Hemostasis
  Tranexamic acid inhibits the breakdown of blood clots by blocking plasminogen activation, reducing fibrinolysis and promoting hemostasis.

Phase 3 pipeline (11)

• Early intravenous tranexamic acid administration · Seoul National University Hospital · Trauma / Hemorrhage / Emergency Medicine
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding in acute trauma and hemorrhage.
• Before CPB Tranexamic Acid · Hamilton Health Sciences Corporation · Cardiovascular / Surgery
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, reducing blood loss during cardiopulmonary bypass surgery.
• No tranexamic acid · Sunnybrook Health Sciences Centre · Hematology / Hemostasis
  Tranexamic acid is an antifibrinolytic agent that inhibits plasminogen activation, reducing fibrin degradation and promoting blood clot stability.
• TXA Nebulization · Post Graduate Institute of Medical Education and Research, Chandigarh · Trauma, Hematology
  TXA nebulization works by stabilizing blood clots and preventing their breakdown.
• Epsilon-aminocaproic acid administered · Montefiore Medical Center · Hematology / Hemostasis
  Epsilon-aminocaproic acid inhibits fibrinolysis by blocking plasminogen activation and plasmin activity, thereby reducing excessive bleeding.
• Exacyl® · University Hospital, Brest · Hematology / Hemostasis
  Exacyl (tranexamic acid) inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding.
• Tranexamic Acid administered · Montefiore Medical Center · Hematology / Hemostasis
  Tranexamic acid inhibits the conversion of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.
• After CPB Tranexamic Acid · Hamilton Health Sciences Corporation · Cardiovascular / Surgery
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, reducing blood loss during and after cardiopulmonary bypass surgery.
• Tranexamic acid tablets · Carlos A Acosta-Olivo · Hematology / Hemostasis
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing blood clot breakdown and promoting hemostasis.
• First placebo, than Tranexamic acid. · University Hospital, Saarland · Hematology / Surgery
  Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding.
• Tranexamic Acid (Intravenous) · The New England Baptist Hospital · Hematology / Hemostasis
  Tranexamic acid inhibits the conversion of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.