Last reviewed · How we verify
Tranexamic Acid Irrigation
Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding during surgical procedures when applied as a local irrigation.
Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding during surgical procedures when applied as a local irrigation. Used for Reduction of perioperative bleeding in orthopedic and general surgical procedures.
At a glance
| Generic name | Tranexamic Acid Irrigation |
|---|---|
| Also known as | TXA |
| Sponsor | University of Wisconsin, Madison |
| Drug class | Antifibrinolytic agent |
| Target | Plasminogen / Plasmin |
| Modality | Small molecule |
| Therapeutic area | Surgery / Hemostasis |
| Phase | FDA-approved |
Mechanism of action
Tranexamic acid is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, preventing the breakdown of fibrin clots. When used as a surgical irrigation solution, it acts locally at the surgical site to stabilize clot formation and reduce perioperative blood loss. This mechanism is particularly useful in orthopedic and other surgical procedures where local hemostasis is critical.
Approved indications
- Reduction of perioperative bleeding in orthopedic and general surgical procedures
Common side effects
- Local tissue irritation
- Allergic reaction
Key clinical trials
- Epinephrine-Added Irrigation Versus Intravenous Tranexamic Acid in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial (NA)
- A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery (PHASE4)
- Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
- Tranexamic Acid in Adult Spinal Deformity Surgery (PHASE3)
- Tranexamic Acid to Reduce Blood Loss in Spine Surgery (PHASE2, PHASE3)
- Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage (PHASE2)
- Efficacy and Safety of Retrograde Intraarticular Injection, Topical Soaking of Tranexamic Acid (TXA), or Placebo in Femoral Neck Fractured Patients Undergoing Cementless Bipolar Hemiarthroplasty (NA)
- Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |