{"id":"tranexamic-acid-irrigation","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, preventing the breakdown of fibrin clots. When used as a surgical irrigation solution, it acts locally at the surgical site to stabilize clot formation and reduce perioperative blood loss. This mechanism is particularly useful in orthopedic and other surgical procedures where local hemostasis is critical.","oneSentence":"Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding during surgical procedures when applied as a local irrigation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:40.892Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of perioperative bleeding in orthopedic and general surgical procedures"}]},"trialDetails":[{"nctId":"NCT07442643","phase":"NA","title":"Epinephrine-Added Irrigation Versus Intravenous Tranexamic Acid in Arthroscopic Rotator Cuff Repair: A Prospective Randomized Controlled Trial","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi","startDate":"2021-05-01","conditions":"Rotator Cuff Tear","enrollment":80},{"nctId":"NCT05441592","phase":"PHASE4","title":"A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2022-08-15","conditions":"Hematoma Postoperative","enrollment":107},{"nctId":"NCT06806241","phase":"","title":"Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery","status":"RECRUITING","sponsor":"Bezmialem Vakif University","startDate":"2025-01-01","conditions":"Bleeding, Tooth Extraction","enrollment":20},{"nctId":"NCT03553186","phase":"PHASE3","title":"Tranexamic Acid in Adult Spinal Deformity Surgery","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2018-07-11","conditions":"Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical","enrollment":100},{"nctId":"NCT02314988","phase":"PHASE2, PHASE3","title":"Tranexamic Acid to Reduce Blood Loss in Spine Surgery","status":"RECRUITING","sponsor":"Columbia University","startDate":"2020-06-15","conditions":"Spinal Injuries, Spinal Deformity","enrollment":252},{"nctId":"NCT05554211","phase":"PHASE2","title":"Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage","status":"WITHDRAWN","sponsor":"Northwestern University","startDate":"2022-07-12","conditions":"Breast Cancer, BRCA Mutation","enrollment":""},{"nctId":"NCT06289478","phase":"NA","title":"Efficacy and Safety of Retrograde Intraarticular Injection, Topical Soaking of Tranexamic Acid (TXA), or Placebo in Femoral Neck Fractured Patients Undergoing Cementless Bipolar Hemiarthroplasty","status":"RECRUITING","sponsor":"King Chulalongkorn Memorial Hospital","startDate":"2024-07-03","conditions":"Femoral Neck Fracture","enrollment":75},{"nctId":"NCT06435832","phase":"NA","title":"Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence","status":"ACTIVE_NOT_RECRUITING","sponsor":"Recep Tayyip Erdogan University","startDate":"2024-05-16","conditions":"Alveolar Osteitis","enrollment":98},{"nctId":"NCT04594408","phase":"PHASE4","title":"Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery","status":"COMPLETED","sponsor":"Panam Clinic","startDate":"2020-09-01","conditions":"Rotator Cuff Injuries, Rotator Cuff Tears, Subacromial Impingement","enrollment":128},{"nctId":"NCT06188052","phase":"PHASE4","title":"Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2023-08-01","conditions":"To Calculate Total Blood Loss Immediately Postoperative","enrollment":45},{"nctId":"NCT05947435","phase":"NA","title":"Tranexamic Acid in Percutaneous Nephrolithotomy","status":"COMPLETED","sponsor":"Haseki Training and Research Hospital","startDate":"2022-01-01","conditions":"Percutaneous Nephrolithotomy, Intraoperative Use of Tranexamic Acid","enrollment":75},{"nctId":"NCT05913466","phase":"NA","title":"Intraprostatic Injection of Tranexamic Acid Decrease Blood Loss During Monopolar TURP","status":"UNKNOWN","sponsor":"Benha University","startDate":"2023-06-20","conditions":"Benign Prostatic Hyperplasia, Transurethral Resection of the Prostate, Tranexamic Acid","enrollment":60},{"nctId":"NCT04372940","phase":"PHASE4","title":"Tranexamic Acid in Gender Mastectomy","status":"WITHDRAWN","sponsor":"University of Wisconsin, Madison","startDate":"2023-01","conditions":"Surgery","enrollment":""},{"nctId":"NCT05453266","phase":"NA","title":"Arthroscopic Rotator Cuff Repair Performed With Intraarticular Tranexamic Acid Could it Provide Improved Visual Clarity and Less Post-operative Pain? A Prospective, Double Blind, Randomized Study of 64 Patients.","status":"COMPLETED","sponsor":"Florence Nightingale Hospital, Istanbul","startDate":"2022-01-01","conditions":"Rotator Cuff Tears, Rotator Cuff Rupture, Tranexamic Acid","enrollment":63},{"nctId":"NCT05152186","phase":"PHASE3","title":"Compare Between the Effect of Topical Tranexamic Acid Versus Hydrogen Peroxide on Blood Loss in Spine Surgeries","status":"UNKNOWN","sponsor":"Minia University","startDate":"2021-06-01","conditions":"Blood Loss","enrollment":120},{"nctId":"NCT04555343","phase":"PHASE1, PHASE2","title":"Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention","status":"COMPLETED","sponsor":"Fraser Health","startDate":"2021-03-01","conditions":"Urologic Diseases, Prostate Cancer, Bladder Cancer","enrollment":14},{"nctId":"NCT03353259","phase":"PHASE2, PHASE3","title":"Tocilizumab (RoActemra) and Tranexamic Acid (Cyklokapron) Used as Adjuncts to Chronic Subdural Hematoma Surgery","status":"TERMINATED","sponsor":"Oslo University Hospital","startDate":"2017-11-28","conditions":"Chronic Subdural Hematoma","enrollment":382},{"nctId":"NCT04367155","phase":"NA","title":"Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.","status":"UNKNOWN","sponsor":"Kafrelsheikh University","startDate":"2019-09-01","conditions":"Renal Stones, Nephrolithiasis","enrollment":200},{"nctId":"NCT04628676","phase":"NA","title":"Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity","status":"COMPLETED","sponsor":"Haseki Training and Research Hospital","startDate":"2017-02-01","conditions":"Rotator Cuff Tears","enrollment":100},{"nctId":"NCT03706339","phase":"NA","title":"Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-11-01","conditions":"Cesarean Section Complications","enrollment":450},{"nctId":"NCT03505502","phase":"NA","title":"Reducing Blood Loss During Cesarean Myomectomy With Tranexamic Acid","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-01-01","conditions":"Cesarean Section Complications","enrollment":120},{"nctId":"NCT03923062","phase":"PHASE4","title":"Different Dermatological Approaches the Treatment of Melasma","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-02-01","conditions":"Melasma","enrollment":40},{"nctId":"NCT02993341","phase":"PHASE3","title":"Topical Tranexamic Acid (TXA) in Hip Fractures","status":"COMPLETED","sponsor":"Sault Area Hospital","startDate":"2016-11","conditions":"Hip Fracture, Anemia","enrollment":65},{"nctId":"NCT01866943","phase":"PHASE2","title":"Role of Topical Tranexamic Acid in Total Hip Arthroplasty","status":"TERMINATED","sponsor":"Northwell Health","startDate":"2011-11","conditions":"Post Operative Blood Loss","enrollment":41},{"nctId":"NCT02312440","phase":"PHASE3","title":"Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2014-10","conditions":"Blood Loss","enrollment":173},{"nctId":"NCT01895101","phase":"PHASE4","title":"The Effect on Blood Loss of Topical and Intravenous Tranexamic Acid in Cardiac Surgery Patients","status":"COMPLETED","sponsor":"Amphia Hospital","startDate":"2013-10","conditions":"Blood Loss, Tranexamic Acid, Cardiac Surgery","enrollment":750},{"nctId":"NCT01881568","phase":"PHASE3","title":"Efficacy Comparison of Topical and Intravenous Tranexamic Acid to Reduce the Number of Blood Transfusions in TKA","status":"COMPLETED","sponsor":"Hospital Universitario La Paz","startDate":"2013-01","conditions":"Blood Loss","enrollment":79}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TXA"],"phase":"marketed","status":"active","brandName":"Tranexamic Acid Irrigation","genericName":"Tranexamic Acid Irrigation","companyName":"University of Wisconsin, Madison","companyId":"university-of-wisconsin-madison","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing bleeding during surgical procedures when applied as a local irrigation. 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