Lidocaine topical — Competitive Intelligence Brief

Lidocaine topical (Lidocaine topical) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic. Area: Pain management / Dermatology.

marketed Local anesthetic Voltage-gated sodium channels Pain management / Dermatology Small molecule

Target snapshot

Lidocaine topical (Lidocaine topical) — Ain Shams University. Lidocaine blocks sodium channels in nerve cell membranes, preventing depolarization and transmission of pain signals.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Lidocaine topical TARGET	Lidocaine topical	Ain Shams University	marketed	Local anesthetic	Voltage-gated sodium channels
Buffered Articaine Hydrochloride + Epinephrine	Buffered Articaine Hydrochloride + Epinephrine	Ohio State University	marketed	Local anesthetic with vasoconstrictor	Voltage-gated sodium channels; alpha-1 adrenergic receptors (epinephrine component)
Lidocaine plus adrenaline	Lidocaine plus adrenaline	University of Santiago de Compostela	marketed	Local anesthetic with vasopressor	Voltage-gated sodium channels; alpha-1 and beta-1 adrenergic receptors
Levobupivacaine and Fentanyl	Levobupivacaine and Fentanyl	Hamad Medical Corporation	marketed	Local anesthetic with opioid analgesic combination	Voltage-gated sodium channels; mu-opioid receptor
lidocaine with propofol	lidocaine with propofol	Imam Abdulrahman Bin Faisal University	marketed	Local anesthetic and sedative-hypnotic combination	Voltage-gated sodium channels (lidocaine); GABA-A receptors (propofol)
lignocaine+dexamethasone	lignocaine+dexamethasone	Aligarh Muslim University	marketed	Local anesthetic + corticosteroid combination	Voltage-gated sodium channels (lignocaine); glucocorticoid receptor (dexamethasone)
Paroxetine+Lamotrigine	Paroxetine+Lamotrigine	Ministry of Health & Welfare, Korea	marketed	SSRI + anticonvulsant mood stabilizer combination	Serotonin transporter (SERT); voltage-gated sodium channels; glutamate release modulation

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic class)

1. University of California, San Diego · 3 drugs in this class
2. Durect · 3 drugs in this class
3. Pacira Pharmaceuticals, Inc · 3 drugs in this class
4. Wake Forest University Health Sciences · 3 drugs in this class
5. Medical University of Vienna · 3 drugs in this class
6. Imperial College London · 2 drugs in this class
7. Hvidovre University Hospital · 2 drugs in this class
8. Innocoll · 2 drugs in this class
9. George Washington University · 2 drugs in this class
10. Guy's and St Thomas' NHS Foundation Trust · 2 drugs in this class