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lignocaine+dexamethasone
Lignocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection site.
Lignocaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection site. Used for Local anesthesia with anti-inflammatory effect for injection or infiltration, Pain relief with reduced inflammation in localized conditions.
At a glance
| Generic name | lignocaine+dexamethasone |
|---|---|
| Sponsor | Aligarh Muslim University |
| Drug class | Local anesthetic + corticosteroid combination |
| Target | Voltage-gated sodium channels (lignocaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Anesthesia, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Lignocaine is a local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and blocking pain signal transmission. Dexamethasone is a corticosteroid that suppresses inflammatory responses by inhibiting phospholipase A2 and reducing prostaglandin and cytokine production. Together, this combination provides both anesthetic and anti-inflammatory effects for localized pain and inflammation management.
Approved indications
- Local anesthesia with anti-inflammatory effect for injection or infiltration
- Pain relief with reduced inflammation in localized conditions
Common side effects
- Local irritation or burning at injection site
- Allergic reaction to lignocaine
- Systemic corticosteroid effects with repeated use
- Numbness or paresthesia
Key clinical trials
- Predictors of Treatment Response to Stellate Ganglion Block in Cervical Radicular Pain
- Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study) (PHASE2)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Magnesium Sulfate Versus Other Anesthesia Drugs to Reduce Agitation After Adenotonsillectomy in Pediatric Patients (NA)
- Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy (PHASE3)
- Pericapsular Nerve Group Block Added to Intra-articular Corticosteroid Injection in the Treatment of Hip Pain
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lignocaine+dexamethasone CI brief — competitive landscape report
- lignocaine+dexamethasone updates RSS · CI watch RSS
- Aligarh Muslim University portfolio CI