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Lidocaine topical
Lidocaine blocks sodium channels in nerve cell membranes, preventing depolarization and transmission of pain signals.
Lidocaine blocks sodium channels in nerve cell membranes, preventing depolarization and transmission of pain signals. Used for Localized pain relief on skin and mucous membranes, Post-herpetic neuralgia, Minor cuts, burns, and abrasions.
At a glance
| Generic name | Lidocaine topical |
|---|---|
| Also known as | lidocaine spray, Lidocaine hydrochloride topical solution, USP, 4%, Anestol pomade(lidocaine), Tramadol hydrochloride, Fentanyl citrate |
| Sponsor | Ain Shams University |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Dermatology |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers. This prevents the generation and propagation of action potentials, thereby blocking pain sensation in the area where it is applied topically. It has a rapid onset and is commonly used for localized pain relief on intact or damaged skin.
Approved indications
- Localized pain relief on skin and mucous membranes
- Topical anesthesia for minor procedures
- Relief of itching and burning sensations
Common side effects
- Local skin irritation or erythema
- Allergic contact dermatitis
- Systemic toxicity (if absorbed in large amounts)
Key clinical trials
- The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster (NA)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults (PHASE4)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- Virtual Reality for Port-a-Cath Access (NA)
- EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers (PHASE2)
- Efficacy and Safety of TargetCool + Benev Exosomes in Patients With Hair Thinning (NA)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine topical CI brief — competitive landscape report
- Lidocaine topical updates RSS · CI watch RSS
- Ain Shams University portfolio CI