SARS-CoV-2 spike protein — Drug Target
All drugs that target SARS-CoV-2 spike protein — marketed and clinical-stage. Includes 13 drug classes acting on this target.
Drug classes
mRNA vaccine · vaccine · Monoclonal antibody · Protein subunit vaccine · viral vector vaccine · Viral vector vaccine · Monoclonal antibody combination (neutralizing antibodies) · Recombinant protein vaccine · Antiviral · COVID-19 vaccine · monoclonal antibody · Recombinant protein vaccine with adjuvant
Marketed (26)
- COMIRNATY intramuscular injection · Pfizer · mRNA vaccine
- BNT162b2 Bivalent (WT/OMI BA.1) · Pfizer · mRNA vaccine · Immunology
- Tozinameran 12 Years of age and older · Pfizer · vaccine · Immunology
- AntiCov-220 · Nguyen Thi Trieu, MD · Monoclonal antibody · Infectious disease
AntiCov-220 is an antibody that targets the SARS-CoV-2 spike protein. - BNT162b4 5 mcg · Pfizer · vaccine · Immunology
- BNT162b2 (Omi XBB.1.5) · Pfizer · mRNA vaccine · Immunology
- Variant-adapted BNT162b2 (Omicron XBB.1.5) 10 microgram dose · Pfizer · mRNA vaccine · Immunology
- mRNA-1273 vaccine · University Health Network, Toronto · mRNA vaccine · Immunology / Infectious Disease
mRNA-1273 is an mRNA vaccine that instructs cells to produce the SARS-CoV-2 spike protein, triggering an immune response to prevent COVID-19 infection. - protein subunit: Novavax COVID-19 vaccine · Novavax · Protein subunit vaccine · Immunology / Infectious Disease
The Novavax COVID-19 vaccine delivers recombinant SARS-CoV-2 spike protein nanoparticles with an adjuvant to stimulate immune responses against the virus. - MVC-COV1901(3 Months) · Taoyuan General Hospital · Protein subunit vaccine · Immunology / Infectious Disease
MVC-COV1901 is a recombinant protein subunit vaccine that stimulates immune responses against SARS-CoV-2 spike protein to prevent COVID-19 infection. - Ad26.COV2.S vaccine · University Medical Center Groningen · viral vector vaccine · Immunology / Infectious Disease
Ad26.COV2.S is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate immune responses against COVID-19. - BNT162b2 (2025/2026 formulation) · Pfizer · vaccine · Immunology
- TT · CanSino Biologics Inc. · Viral vector vaccine · Immunology / Infectious Disease
TT is a recombinant adenovirus type 5 vector-based vaccine that expresses the SARS-CoV-2 spike protein to elicit immune responses against COVID-19. - Combination BNT162b2 and BNT162b2 OMI · Pfizer · mRNA vaccine · Infectious Disease
A combination of two mRNA-based vaccines that work together to prevent and treat COVID-19. - batch 3 of Ad5-nCoV · Jiangsu Province Centers for Disease Control and Prevention · viral vector vaccine · Immunology / Infectious Disease
Ad5-nCoV is a recombinant adenovirus type 5 vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate immune responses against COVID-19. - BNT162b7 Bivalent (Original/OMI BA.4/BA.5) · Pfizer · mRNA vaccine · Infectious Disease
BNT162b7 Bivalent is a mRNA-based vaccine targeting SARS-CoV-2 spike protein. - batch 1 of Ad5-nCoV · Jiangsu Province Centers for Disease Control and Prevention · viral vector vaccine · Immunology / Infectious Disease
Ad5-nCoV is a recombinant adenovirus type 5 vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate immune responses against COVID-19. - BNT162b5 Bivalent (WT/OMI BA.2) · Pfizer · mRNA vaccine · Immunology
- Famtozinameran 5 to 11 Years of age · Pfizer · Monoclonal antibody · Infectious Disease
- Intramuscularly administered Ad5-nCoV vaccine · Jiangsu Province Centers for Disease Control and Prevention · viral vector vaccine · Immunology / Infectious Disease
An adenovirus type 5 (Ad5) vector vaccine delivers the SARS-CoV-2 spike protein gene intramuscularly to stimulate cellular and humoral immune responses against COVID-19. - Tozinameran (BNT162b2) / Riltozinameran (BNT162b2 OMI BA.1) · Pfizer · vaccine · Immunology
- BNT162b7 Monovalent (OMI BA.4/BA.5) · Pfizer · vaccine · Immunology
- BNT162b6 Bivalent (Original/OMI BA.4/BA.5) · Pfizer · vaccine · Immunology
- Regeneron Casirivimab + Imdevimab · Erin McCreary · Monoclonal antibody combination (neutralizing antibodies) · Infectious Disease / Virology
This combination of two monoclonal antibodies binds to the SARS-CoV-2 spike protein to neutralize the virus and prevent infection of human cells. - Tozinameran 6 months to 4 years of age · Pfizer · vaccine · Immunology
- COVID-19 vaccination · University Medical Center Groningen · vaccine · Immunology / Infectious Disease
COVID-19 vaccines train the immune system to recognize and neutralize the SARS-CoV-2 virus by inducing antibody and T-cell responses against viral antigens.
Phase 3 pipeline (35)
- mRNA-1403 · ModernaTX, Inc. · mRNA vaccine · Infectious Disease
mRNA-1403 is an mRNA-based vaccine designed to encode for the SARS-CoV-2 spike protein. - SpikoGen vaccine · Vaxine Pty Ltd · Recombinant protein vaccine · Immunology / Infectious Disease
SpikoGen is a recombinant protein vaccine designed to stimulate immune responses against SARS-CoV-2 spike protein. - KOCITAF · Professor Francois Venter · Antiviral · Infectious Disease
KOCITAF is a small molecule drug that targets the SARS-CoV-2 virus. - SHEN26 capsule · Shenzhen Kexing Pharmaceutical Co., Ltd. · vaccine · Infectious Disease
SHEN26 capsule is a vaccine that targets the SARS-CoV-2 spike protein. - ChAdOx1-S vaccine · Vaxxinity, Inc. · Viral vector vaccine · Immunology / Infectious Disease
ChAdOx1-S is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate adaptive immune responses against COVID-19. - THR-100 · Bharat Biotech International Limited · COVID-19 vaccine · Infectious disease
THR-100 is a recombinant human monoclonal antibody that targets the SARS-CoV-2 spike protein. - VIR-7831 · National Institute of Allergy and Infectious Diseases (NIAID) · Infectious Disease
VIR-7831 is a monoclonal antibody that targets the SARS-CoV-2 spike protein. - Clover SCB-2019 · D'Or Institute for Research and Education · Recombinant protein vaccine · Immunology / Infectious Disease
Clover SCB-2019 is a recombinant protein vaccine candidate designed to elicit immune responses against SARS-CoV-2 by presenting stabilized spike protein trimers. - Astrazenica vaccine · Samia Hassan El-Shishtawy · Viral vector vaccine · Immunology / Infectious Disease
The AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19) uses a replication-deficient chimpanzee adenovirus vector to deliver the SARS-CoV-2 spike protein gene, triggering immune responses against the virus. - SARS-CoV-2 Vaccine · Hospitales Universitarios Virgen del Rocío · vaccine · Immunology / Infectious Disease
This vaccine trains the immune system to recognize and attack SARS-CoV-2 virus by presenting viral antigens or genetic instructions to produce them. - SARS-CoV-2 rS/Matrix M1-Adjuvant · Novavax · vaccine · Infectious Disease
SARS-CoV-2 rS/Matrix M1-Adjuvant is a vaccine that uses the SARS-CoV-2 spike protein and Matrix M1 adjuvant to stimulate an immune response against SARS-CoV-2. - Novavax COVID-19 Vaccine · Novavax · Protein subunit vaccine · Immunology
Novavax COVID-19 Vaccine uses recombinant spike protein nanoparticles with a saponin-based adjuvant to stimulate immune responses against SARS-CoV-2. - Profilaxis recommended · Maimónides Biomedical Research Institute of Córdoba · vaccine · Infectious Disease
This drug targets the SARS-CoV-2 spike protein to prevent infection. - bivalent rLP2086 · Pfizer · vaccine · Infectious Disease
bivalent rLP2086 is a vaccine that targets the SARS-CoV-2 spike protein. - VLA2001 - adolescent part · Valneva Austria GmbH · vaccine · Infectious Disease
VLA2001 is a COVID-19 vaccine that uses a recombinant, replication-incompetent chimpanzee adenovirus vector to express the SARS-CoV-2 spike protein. - AZD 1222 · University Medicine Greifswald · Viral vector vaccine · Immunology / Infectious Disease
AZD1222 is a viral vector vaccine that delivers genetic instructions for the SARS-CoV-2 spike protein to stimulate immune responses against COVID-19. - VYD2311-MD · Invivyd, Inc. · monoclonal antibody · Infectious Disease
VYD2311-MD is a monoclonal antibody that targets the SARS-CoV-2 spike protein. - TURCOVAC · Health Institutes of Turkey · vaccine · Infectious Disease
TURCOVAC is a vaccine that works by stimulating the body's immune system to produce antibodies against the SARS-CoV-2 virus. - Sputnik Light · Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation · Viral vector vaccine · Immunology / Infectious Disease
Sputnik Light is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate adaptive immune responses against COVID-19. - V114 · Merck Sharp & Dohme LLC · vaccine · Infectious Disease
V114 is a recombinant vesicular stomatitis virus (VSV) vector-based vaccine that expresses the SARS-CoV-2 spike protein. - Tixagevimab Cilgavimab · Azienda Ospedaliera Universitaria Integrata Verona · Monoclonal antibody · Infectious disease
Tixagevimab and cilgavimab are monoclonal antibodies that bind to the SARS-CoV-2 spike protein, preventing viral entry into host cells. - ChAdOx1 nCoV-19 · EuBiologics Co.,Ltd · Viral vector vaccine · Immunology / Infectious Disease
ChAdOx1 nCoV-19 is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene into cells to trigger an immune response against COVID-19. - BBV154(Intranasal) & covaxin · Bharat Biotech International Limited · Viral vector vaccine · Immunology / Infectious Disease
BBV154 is an intranasal booster vaccine designed to enhance immune response against SARS-CoV-2 when administered after Covaxin (inactivated COVID-19 vaccine) priming. - ChAdOx1 nCoV-19 single dose + paracetamol · University of Oxford · Viral vector vaccine · Immunology / Infectious Disease
ChAdOx1 nCoV-19 is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate immune responses against COVID-19, combined with paracetamol for symptomatic relief. - SP IPT · Institute of Tropical Medicine, Belgium · vaccine · Infectious Disease
SP IPT is a vaccine that targets the SARS-CoV-2 spike protein. - BBV154 Intranasal Vaccine · Bharat Biotech International Limited · Viral vector vaccine · Immunology / Infectious Disease
BBV154 is an intranasal recombinant vaccine that stimulates mucosal and systemic immune responses against SARS-CoV-2 by delivering viral antigens directly to respiratory tract tissues. - SARS-CoV-2 rS antigen/Matrix-M Adjuvant · Novavax · Recombinant protein vaccine with adjuvant · Immunology / Infectious Disease
This vaccine delivers the SARS-CoV-2 spike protein antigen with Matrix-M adjuvant to stimulate immune responses against COVID-19. - ChAdOx1 nCoV-19 two dose + paracetamol · University of Oxford · Viral vector vaccine · Immunology / Infectious Disease
ChAdOx1 nCoV-19 is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate immune responses against COVID-19. - AstraZeneca/Fiocruz · D'Or Institute for Research and Education · Viral vector vaccine · Immunology / Infectious Disease
This is the AstraZeneca/Fiocruz COVID-19 vaccine (ChAdOx1 nCoV-19, Covishield), which uses a replication-deficient chimpanzee adenovirus vector carrying the SARS-CoV-2 spike protein gene to induce immune responses. - CoronaVac/BNT162b2 · Institut Pasteur de Tunis · vaccine · Immunology / Infectious Disease
This is a combination COVID-19 vaccine regimen using CoronaVac (inactivated virus vaccine) followed by BNT162b2 (mRNA vaccine) to stimulate immune responses against SARS-CoV-2. - mRNA-1345 · ModernaTX, Inc. · mRNA vaccine · Infectious Disease
mRNA-1345 is an mRNA-based vaccine designed to prevent COVID-19 infection by inducing an immune response against the SARS-CoV-2 virus. - MVC-COV1901 · Medigen Vaccine Biologics Corp. · Protein subunit vaccine · Immunology / Infectious Disease
MVC-COV1901 is a protein subunit vaccine that stimulates immune responses against SARS-CoV-2 by presenting viral spike protein antigens to the immune system. - NVX-CoV2515 · Novavax · Recombinant protein subunit vaccine · Immunology / Infectious Disease
NVX-CoV2515 is a recombinant protein subunit vaccine that presents the SARS-CoV-2 spike protein to stimulate immune responses against COVID-19 variants. - NVX-CoV2705 Vaccine · Novavax · Recombinant protein subunit vaccine · Immunology / Infectious Disease
NVX-CoV2705 is a recombinant protein subunit vaccine that presents SARS-CoV-2 spike protein antigens to stimulate adaptive immune responses against COVID-19 variants. - Ad26.COV2.S · National Institute of Allergy and Infectious Diseases (NIAID) · Viral vector vaccine · Immunology / Infectious Disease
Ad26.COV2.S is a viral vector vaccine that delivers genetic instructions for the SARS-CoV-2 spike protein to stimulate immune responses against COVID-19.
Phase 2 pipeline (12)
- BNT162b1 · BioNTech SE · mRNA vaccine · Infectious Disease
mRNA-based vaccine - BAY 94-8862 · Bayer · Monoclonal antibody · Infectious disease
BAY 94-8862 is a monoclonal antibody targeting SARS-CoV-2. - CUCART19 · Chi Kong Li · Monoclonal antibody · Infectious Disease
CUCART19 is a monoclonal antibody targeting the SARS-CoV-2 spike protein. - BNT327 Optimized Dose · BioNTech SE · mRNA vaccine · Infectious Disease
BNT327 is a mRNA-based vaccine that encodes for the SARS-CoV-2 spike protein. - CT-P59 · Celltrion · monoclonal antibody · Infectious Disease
CT-P59 is a COVID-19 treatment that works by binding to the SARS-CoV-2 spike protein. - BRII-835 · Brii Biosciences Limited · Monoclonal antibody · Infectious disease
BRII-835 is a monoclonal antibody that targets the SARS-CoV-2 spike protein. - Pfizer COVID-19 mRNA vaccine · Methodist Health System · mRNA vaccine · Infectious Disease
mRNA vaccine that encodes for the SARS-CoV-2 spike protein - Biological: mRNA-1273 · ModernaTX, Inc. · mRNA vaccine · Infectious Disease
mRNA-based vaccine that encodes for the SARS-CoV-2 spike protein - Astra Zeneca COVID-19 vaccine · Vinbiocare Biotechnology Joint Stock Company · viral vector vaccine · Immunology
This viral vector vaccine delivers genetic instructions for the SARS-CoV-2 spike protein to stimulate adaptive immune responses against COVID-19. - COVID-19 Standard Treatment · Dermama Bioteknologi Laboratorium · Infectious Disease
This drug targets the SARS-CoV-2 virus to prevent COVID-19 infection. - BRII-296 · Brii Biosciences Limited · Monoclonal antibody · Infectious disease
BRII-296 is a monoclonal antibody that targets the SARS-CoV-2 spike protein. - Anti-COVID-19 human immunoglobulin · Lifefactors Zona Franca, SAS · Monoclonal antibody · Infectious Diseases
Anti-COVID-19 human immunoglobulin works by providing pre-formed antibodies to neutralize the SARS-CoV-2 virus.