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Sputnik Light
Sputnik Light is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate adaptive immune responses against COVID-19.
Sputnik Light is a viral vector vaccine that delivers the SARS-CoV-2 spike protein gene to stimulate adaptive immune responses against COVID-19. Used for COVID-19 prevention (SARS-CoV-2 infection).
At a glance
| Generic name | Sputnik Light |
|---|---|
| Also known as | vector vaccine to help prevent the SARS-CoV-2-induced coronavirus infection |
| Sponsor | Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation |
| Drug class | Viral vector vaccine |
| Target | SARS-CoV-2 spike protein |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Sputnik Light uses a recombinant adenovirus type 5 (Ad5) as a viral vector to introduce genetic material encoding the SARS-CoV-2 spike protein into host cells. This triggers both cellular and humoral immune responses, generating T-cell and antibody-mediated immunity against the virus. It is administered as a single-dose vaccine or as a booster component in heterologous prime-boost regimens.
Approved indications
- COVID-19 prevention (SARS-CoV-2 infection)
Common side effects
- Injection site pain or swelling
- Fever
- Fatigue
- Headache
- Myalgia
Key clinical trials
- Study of "Sputnik Lite" for the Prevention of COVID-19 With Altered Antigenic Composition. (PHASE3)
- Study to Evaluate Efficacy, Immunogenicity and Safety of the Sputnik-Light (PHASE3)
- An Open Study on the Safety, Tolerability, and Immunogenicity of "Sputnik Light" Vaccine (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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