HMG-CoA reductase — Drug Target

All drugs that target HMG-CoA reductase — marketed and clinical-stage. Includes 10 drug classes acting on this target.

Drug classes

HMG-CoA reductase inhibitor (statin) · Statin (natural/herbal) · Statins · HMG-CoA Reductase Inhibitor · HMG-CoA reductase inhibitor · Statin (HMG-CoA reductase inhibitor) · Statin combination / Lipid-lowering agent · HMG-CoA reductase inhibitor (Statin) · statin · Lipid-lowering agent

Marketed (41)

• Lipitor · Pfizer Inc. · HMG-CoA reductase inhibitor (statin) · Metabolic
  Selective competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
• Red Yeast Rice Pill · Shiraz University of Medical Sciences · Statin (natural/herbal) · Cardiovascular
  Red yeast rice contains naturally occurring statins that inhibit HMG-CoA reductase, reducing cholesterol synthesis in the liver.
• low-dose atorvastatin · Wakayama Medical University · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Low-dose atorvastatin inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Simvastatin (Zocor) · New York State Psychiatric Institute · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: atorvastatin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• pravastatin, rosuvastatin · Yokohama City University Medical Center · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Both pravastatin and rosuvastatin inhibit HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Double Atorvastatin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Double Atorvastatin is a statin that inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Atorvastatin (Lipitor) · University of Chicago · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels in the blood.
• Pitavastatin (NK-104) · Kowa Research Institute, Inc. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Pitavastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Pitavastin 4mg · University of Kansas Medical Center · Statins · Metabolic
• High intensity statin monotherapy · Korea University Anam Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  High-intensity statin monotherapy reduces LDL cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis.
• Lescol · Novartis · HMG-CoA Reductase Inhibitor · Metabolic
  Fluvastatin sodium inhibits HMG-CoA reductase, reducing cholesterol biosynthesis and increasing LDL receptor activity, lowering plasma cholesterol.
• rosuvastatin 7 days · Radboud University Medical Center · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Rosuvastatin; improvement of lipid profile · AstraZeneca · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol and triglycerides while raising HDL cholesterol.
• Rosuvastatin (Crestor) · Minneapolis Heart Institute Foundation · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step of cholesterol synthesis in the liver.
• Rosuvastatin alone · Gachon University Gil Medical Center · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Statin (simvastatin) · University of Aarhus · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Statins, HMG CoA · National Heart, Lung, and Blood Institute (NHLBI) · HMG-CoA reductase inhibitor · Cardiovascular
  Statins inhibit HMG-CoA reductase, the enzyme that catalyzes the rate-limiting step in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Atorvastatin (Lipinon) · Seoul National University Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• High dose potent statin · University of Florida · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  High-dose potent statins inhibit HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels in the blood.
• Other Statin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• hydration plus rosuvastatin therapy · Shenyang Northern Hospital · Statin (HMG-CoA reductase inhibitor) · Cardiovascular
  Hydration plus rosuvastatin therapy combines fluid replacement with HMG-CoA reductase inhibition to improve hydration status and reduce cholesterol synthesis.
• HMG-CoA Reductase Inhibitor · Seoul National University Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  HMG-CoA reductase inhibitors block the enzyme that catalyzes the rate-limiting step of cholesterol synthesis, reducing hepatic cholesterol production and lowering blood LDL cholesterol levels.
• HMG CoA inhibitor · AstraZeneca · Statin (HMG-CoA reductase inhibitor) · Cardiovascular
  HMG-CoA inhibitors block the enzyme HMG-CoA reductase, which catalyzes an early and rate-limiting step in cholesterol synthesis.
• High dose Rosuvastatin · Nanjing First Hospital, Nanjing Medical University · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Atorvastatin (Lipilou) · Chong Kun Dang Pharmaceutical · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels in the blood.
• Lovastatin Tablet · National Taiwan University Hospital · Statin (HMG-CoA reductase inhibitor) · Cardiovascular
  Lovastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Atorvastatin (generic Lipitor) · University of Pennsylvania · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels in the blood.
• Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin · Kuhnil Pharmaceutical Co., Ltd. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  These statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Rosuvastatin(Cresnon®) · Dong-A ST Co., Ltd. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• FLUVASTATIN SODIUM
  Fluvastatin inhibits HMG-CoA reductase, reducing cholesterol synthesis.
• Simvastatin-Methylcellulose · University of Nebraska · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase to lower cholesterol, while methylcellulose acts as a solubility enhancer and sustained-release excipient to improve drug bioavailability.
• LipoCol Forte capsules · National Taiwan University Hospital · Statin combination / Lipid-lowering agent · Cardiovascular
  LipoCol Forte reduces cholesterol levels by inhibiting HMG-CoA reductase and enhancing cholesterol clearance through multiple lipid-lowering pathways.
• LipoCol and Mevacor · Taipei Medical University WanFang Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  LipoCol and Mevacor are statins that inhibit HMG-CoA reductase to reduce cholesterol synthesis in the liver.
• Simvast CR · Hanmi Pharmaceutical Company Limited · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin is an HMG-CoA reductase inhibitor that lowers cholesterol by blocking the enzyme responsible for cholesterol synthesis in the liver.
• High-intensity statin · Jung-min Ahn · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  High-intensity statins inhibit HMG-CoA reductase to potently reduce LDL cholesterol synthesis in the liver.
• high-dose rosuvastatin single administration · Korea University Anam Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Guideline directed statin therapy · Samsung Medical Center · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Statins inhibit HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels in the blood.
• lipid-lowering drug(Statin) · First Affiliated Hospital of Wenzhou Medical University · HMG-CoA reductase inhibitor (Statin) · Cardiovascular
  Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels in the blood.
• Crestor · AstraZeneca · HMG-CoA reductase inhibitor (statin) · Metabolic
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate, a cholesterol precursor.

Phase 3 pipeline (27)

• Immediate high-intensity statin · Beijing Tiantan Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Statins inhibit HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.
• Placebo to Atorvastatin · Amgen · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  This is a Phase 3 trial comparing placebo to atorvastatin, a statin that lowers cholesterol by inhibiting HMG-CoA reductase.
• Placebe of HS-25 and Atorvastatin · Zhejiang Hisun Pharmaceutical Co. Ltd. · statin · Cardiovascular
  Atorvastatin is a statin that inhibits HMG-CoA reductase to lower cholesterol levels.
• Comparator: fluvastatin · Organon and Co · Statin (HMG-CoA reductase inhibitor) · Cardiovascular
  Fluvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• standard statin monotherapy · VA Office of Research and Development · statin · Cardiovascular
  Standard statin monotherapy works by inhibiting HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway.
• [18F]Florastamin Injection · HTA Co., Ltd. · statin · Cardiovascular
  Florastatin is a radiolabeled version of florastatine, a statin used to lower cholesterol levels.
• Comparator: simvastatin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Atorvastatin Calcium 20mg, QD · Kuhnil Pharmaceutical Co., Ltd. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Red yeast rice and atorvastatin · Wenzhou Medical University · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Red yeast rice and atorvastatin work synergistically to inhibit HMG-CoA reductase and reduce cholesterol synthesis, lowering LDL cholesterol and cardiovascular risk.
• [F-18]Florastamin · FutureChem · statin · Cardiovascular
  Florastatin is a radiolabeled version of florastatin, a statin used to lower cholesterol levels.
• Statins with or without ezetimibe · Beijing Anzhen Hospital · HMG-CoA reductase inhibitor · Cardiovascular
  Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol biosynthesis, while ezetimibe inhibits the absorption of cholesterol in the small intestine.
• Delayed high-intensity statin · Beijing Tiantan Hospital · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  A statin formulation designed to achieve high-intensity lipid-lowering effects through delayed or modified release kinetics to reduce LDL cholesterol.
• Atorvastatin alone · Wenzhou Medical University · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: lovastatin · Organon and Co · Statin (HMG-CoA reductase inhibitor) · Cardiovascular
  Lovastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• MK0803, lovastatin · Merck Sharp & Dohme LLC · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Lovastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• MK0733, simvastatin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Atorvastatin 40mg, QD · Daewoong Pharmaceutical Co. LTD. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Background Statin Therapy · Amgen · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Background statin therapy reduces low-density lipoprotein (LDL) cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis.
• LivaloVA · JW Pharmaceutical · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  LivaloVA is a pitavastatin analog designed to lower cholesterol by inhibiting HMG-CoA reductase with enhanced potency and cardiovascular benefits.
• Rosuvastatin active capsule · Sanofi · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• Comparator: statins · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• placebo + Rosuvastatin · Jeil Pharmaceutical Co., Ltd. · HMG-CoA reductase inhibitor · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway.
• Placebo for Rosuvastatin · Merck Sharp & Dohme LLC · statin · Cardiovascular
  Rosuvastatin is a statin that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis.
• OmegaD · OmegaD LLC · Lipid-lowering agent · Cardiovascular
  OmegaD is a small molecule that modulates the activity of a specific enzyme involved in lipid metabolism.
• Comparator: pravastatin · Organon and Co · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Pravastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels and cardiovascular risk.
• Rosuvastatin Calcium 20 MG, QD · Kuhnil Pharmaceutical Co., Ltd. · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  Rosuvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, thereby reducing LDL cholesterol levels.
• LivaloV · JW Pharmaceutical · HMG-CoA reductase inhibitor (statin) · Cardiovascular
  LivaloV is a statin that inhibits HMG-CoA reductase to reduce cholesterol synthesis and lower LDL cholesterol levels.

Phase 2 pipeline (3)

• LDL reduction therapy · Samsung Medical Center · Statins · Cardiovascular
  HMG-CoA reductase inhibitor
• BR5402A-1 · Boryung Pharmaceutical Co., Ltd · HMG-CoA reductase inhibitor · Cardiovascular
  BR5402A-1 is a small molecule that targets the HMG-CoA reductase enzyme.
• Atorvastatin and Dexamethasone · Oriental Neurosurgery Evidence-Based-Study Team · Statins · Cardiovascular
  Atorvastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis, while Dexamethasone is a corticosteroid that suppresses inflammation and immune responses.