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Atorvastatin and Dexamethasone
Atorvastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis, while Dexamethasone is a corticosteroid that suppresses inflammation and immune responses.
Atorvastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis, while Dexamethasone is a corticosteroid that suppresses inflammation and immune responses. Used for Hyperlipidemia, Inflammatory conditions.
At a glance
| Generic name | Atorvastatin and Dexamethasone |
|---|---|
| Sponsor | Oriental Neurosurgery Evidence-Based-Study Team |
| Drug class | Statins |
| Target | HMG-CoA reductase |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 2 |
Mechanism of action
Atorvastatin works by competitively inhibiting HMG-CoA reductase, which is a crucial enzyme in the mevalonate pathway that produces cholesterol. This leads to a decrease in cholesterol levels in the liver and an increase in LDL receptors, resulting in reduced LDL cholesterol levels. Dexamethasone, on the other hand, is a synthetic corticosteroid that has potent anti-inflammatory and immunosuppressive properties, making it useful for treating a variety of conditions, including inflammation and autoimmune diseases.
Approved indications
- Hyperlipidemia
- Inflammatory conditions
Common side effects
- Muscle pain
- Diabetes
- Liver enzyme elevation
Key clinical trials
- Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC (PHASE3)
- Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients (NA)
- The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |