{"id":"atorvastatin-and-dexamethasone","safety":{"commonSideEffects":[{"rate":"null","effect":"Muscle pain"},{"rate":"null","effect":"Diabetes"},{"rate":"null","effect":"Liver enzyme elevation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Atorvastatin works by competitively inhibiting HMG-CoA reductase, which is a crucial enzyme in the mevalonate pathway that produces cholesterol. This leads to a decrease in cholesterol levels in the liver and an increase in LDL receptors, resulting in reduced LDL cholesterol levels. Dexamethasone, on the other hand, is a synthetic corticosteroid that has potent anti-inflammatory and immunosuppressive properties, making it useful for treating a variety of conditions, including inflammation and autoimmune diseases.","oneSentence":"Atorvastatin inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis, while Dexamethasone is a corticosteroid that suppresses inflammation and immune responses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T02:29:33.381Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyperlipidemia"},{"name":"Inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT04631536","phase":"PHASE3","title":"Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC","status":"UNKNOWN","sponsor":"Lebanese American University Medical Center","startDate":"2021-01-10","conditions":"Covid19","enrollment":42},{"nctId":"NCT04607447","phase":"NA","title":"Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients","status":"UNKNOWN","sponsor":"Huashan Hospital","startDate":"2020-08-04","conditions":"Chronic Subdural Hematoma","enrollment":160},{"nctId":"NCT02192320","phase":"PHASE2","title":"The Clinical Study of Atorvastatin and Dexamethasone on Treatment for Chronic Subdural Hematoma in the Patients With Coagulation Disorders","status":"UNKNOWN","sponsor":"Oriental Neurosurgery Evidence-Based-Study Team","startDate":"2014-07","conditions":"Chronic Subdural Hematoma","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Atorvastatin and Dexamethasone","genericName":"Atorvastatin and Dexamethasone","companyName":"Oriental Neurosurgery Evidence-Based-Study Team","companyId":"oriental-neurosurgery-evidence-based-study-team","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Atorvastatin is a medication used to treat conditions such as high cholesterol and has been studied in the context of COVID-19. Dexamethasone is a corticosteroid used to treat conditions such as chronic subdural hematoma and has been studied in the context of COVID-19.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}