HIV reverse transcriptase — Drug Target

All drugs that target HIV reverse transcriptase — marketed and clinical-stage. Includes 28 drug classes acting on this target.

Drug classes

Antiretroviral combination therapy (NRTI + NNRTI) · Nucleoside reverse transcriptase inhibitor (NRTI) · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Antiretroviral combination therapy (nucleoside reverse transcriptase inhibitors + non-nucleoside reverse transcriptase inhibitor) · Antiretroviral combination therapy (NRTI/NtRTI + NNRTI) · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Antiretroviral combination therapy (NNRTI + NRTI + NtRTI) · Nucleoside reverse transcriptase inhibitor combination · Nucleoside Reverse Transcriptase Inhibitor (NRTI) · Antiretroviral combination (NNRTI + NRTIs)

Marketed (48)

• TDF/3TC/EFV · Peking Union Medical College Hospital · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This is a fixed-dose combination antiretroviral regimen that inhibits HIV reverse transcriptase and integrase to suppress viral replication.
• Zidovudine (drug) · Johann Wolfgang Goethe University Hospital · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Zidovudine is a nucleoside reverse transcriptase inhibitor that blocks HIV replication by inhibiting the enzyme reverse transcriptase, preventing the virus from converting its RNA genome into DNA.
• Lamivudine / Abacavir Sulfate · GlaxoSmithKline · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  Lamivudine and abacavir are nucleoside reverse transcriptase inhibitors (NRTIs) that block HIV reverse transcriptase, preventing viral replication by terminating DNA chain elongation.
• Regimen:TDF+3TC+EFV · National Center for AIDS/STD Control and Prevention, China CDC · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This combination regimen inhibits HIV reverse transcriptase and integrase through three antiretroviral agents, preventing viral replication and reducing viral load.
• AZT+3TC+ABV (Trizivir) · Fundacion SEIMC-GESIDA · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  Trizivir is a fixed-dose combination of three nucleoside reverse transcriptase inhibitors (NRTIs) that block HIV reverse transcriptase to prevent viral replication.
• Efavirenz or Nevirapine · University of Aarhus · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Efavirenz and Nevirapine are non-nucleoside reverse transcriptase inhibitors (NNRTIs) that block HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• Arm A: ABC+3TC+NNRTI · Medical Research Council · Antiretroviral combination therapy (nucleoside reverse transcriptase inhibitors + non-nucleoside reverse transcriptase inhibitor) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase through two nucleoside analogs (ABC and 3TC) and one non-nucleoside reverse transcriptase inhibitor (NNRTI), blocking viral replication.
• Emtricitabine/rilpivirine/tenofovir disoproxil fumarate · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Antiretroviral combination therapy (NRTI/NtRTI + NNRTI) · Infectious Disease / Virology
  This combination drug inhibits HIV reverse transcriptase and integrase through three complementary antiretroviral agents, preventing viral replication and reducing viral load.
• Abacavir/lamivudine and efavirenz · GlaxoSmithKline · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This combination of three antiretroviral drugs inhibits HIV replication by blocking reverse transcriptase and integrase enzymes, preventing the virus from copying its genetic material and integrating into host cells.
• Emtricitabine/tenofovir or abacavir/lamivudine · Fundacion SEIMC-GESIDA · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  These are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that block HIV reverse transcriptase, preventing viral RNA from being converted into DNA and integrated into host cells.
• emtricitabine [FTC]/tenofovir [TDF] · Tibotec, Inc · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  This combination of two nucleoside reverse transcriptase inhibitors (NRTIs) blocks HIV reverse transcriptase to prevent viral replication.
• Lamivudine/Zidovudine · Bristol-Myers Squibb · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  This combination of two nucleoside reverse transcriptase inhibitors (NRTIs) blocks HIV reverse transcriptase to prevent viral replication.
• Emtricitabine / Tenofovir · The Miriam Hospital · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Infectious Disease / Virology
  Emtricitabine and tenofovir are nucleoside/nucleotide reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• DOR/3TC/TDF · Prism Health North Texas · Antiretroviral combination therapy (NNRTI + NRTI + NtRTI) · Infectious Disease / Virology
  DOR/3TC/TDF is a fixed-dose combination of three antiretroviral agents that work together to inhibit HIV replication through different mechanisms: reverse transcriptase inhibition and nucleotide reverse transcriptase inhibition.
• TAF/FTC · Göteborg University · Nucleoside reverse transcriptase inhibitor combination · Infectious Disease / Virology
  TAF/FTC is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors that block HIV reverse transcriptase to prevent viral replication.
• Tenofovir/Emtricitabine and efavirenz · GlaxoSmithKline · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase and integrase to block viral replication and reduce viral load in HIV-infected patients.
• Efavirenz (EFV) · Janssen-Cilag S.p.A. · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Efavirenz inhibits HIV reverse transcriptase, blocking the enzyme that converts viral RNA into DNA and preventing HIV replication.
• ZIAGEN® · ViiV Healthcare · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  ZIAGEN (abacavir) is a nucleoside reverse transcriptase inhibitor that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• nucleoside reverse transcriptase inhibitors · French National Agency for Research on AIDS and Viral Hepatitis · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Nucleoside reverse transcriptase inhibitors block the reverse transcriptase enzyme that HIV uses to convert its RNA genome into DNA, preventing viral replication.
• Once-daily ABC+3TC · Medical Research Council · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  ABC+3TC is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors (NRTIs) that blocks HIV reverse transcriptase to prevent viral replication.
• Lamiduvine (Epivir) · Catholic University of the Sacred Heart · Nucleoside Reverse Transcriptase Inhibitor (NRTI) · Metabolic
  Lamiduvine inhibits the HIV reverse transcriptase enzyme, preventing viral RNA from being converted into DNA, thus halting viral replication.
• Doravirine + tenofovir DF + lamivudine · Instituto Mexicano del Seguro Social · Antiretroviral combination (NNRTI + NRTIs) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase and integrase to block viral replication at multiple steps.
• Abacavir/lamivudine/zidovudine · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  This combination of three nucleoside reverse transcriptase inhibitors blocks HIV reverse transcriptase to prevent viral replication.
• Nevirapine (Viramune) · Germans Trias i Pujol Hospital · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Nevirapine inhibits HIV reverse transcriptase, blocking the enzyme that converts viral RNA into DNA and preventing HIV replication.
• Twice-daily ABC+3TC · Medical Research Council · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  ABC (abacavir) and 3TC (lamivudine) are nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• AZT · Johns Hopkins Bloomberg School of Public Health · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  AZT (zidovudine) inhibits HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating within host cells.
• Abacavir sulfate, Lamivudine and Zidovudine · National Institute of Allergy and Infectious Diseases (NIAID) · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  This combination of three nucleoside reverse transcriptase inhibitors (NRTIs) blocks HIV reverse transcriptase to prevent viral replication.
• Vaginal TFV Gel · University of Washington · Nucleotide reverse transcriptase inhibitor (microbicide) · Infectious Disease / HIV Prevention
  Tenofovir (TFV) gel applied vaginally blocks HIV reverse transcriptase to prevent sexual transmission of HIV.
• Generic HAART Triomune : d4T, 3TC, NVP · University of KwaZulu · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  Triomune is a fixed-dose combination antiretroviral therapy that inhibits HIV reverse transcriptase and protease to suppress viral replication.
• rilpivirina + emtricitabina + tenofovir · Hospital Universitari Vall d'Hebron Research Institute · Antiretroviral combination therapy (NNRTI + 2 NRTIs) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase through three complementary mechanisms: rilpivirina as a non-nucleoside reverse transcriptase inhibitor (NNRTI) and emtricitabina and tenofovir as nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs).
• Tenofovir disoproxil/emtricitabine/rilpivirine · Sheba Medical Center · Antiretroviral combination (NRTI + NNRTI) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase and integrase to block viral replication and reduce viral load in HIV-infected patients.
• tenofovir + abacavir + efavirenz · Hospital Clinic of Barcelona · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This combination of three antiretroviral drugs inhibits HIV replication by blocking reverse transcriptase and integrase enzymes, preventing the virus from copying its genetic material and integrating into host cells.
• FTC-TDF PrEP · University of Washington · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease / Virology
  FTC-TDF PrEP blocks reverse transcriptase in HIV, preventing the virus from converting its RNA genome into DNA and integrating into host cells.
• Tenofovir alafenamide/emtricitabine · ViiV Healthcare · Nucleotide/nucleoside reverse transcriptase inhibitor combination · Infectious Disease
  Tenofovir alafenamide and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• FTC/TAF · ViiV Healthcare · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease
  FTC/TAF is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors that blocks HIV reverse transcriptase to prevent viral replication.
• EFV · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  EFV (efavirenz) is a non-nucleoside reverse transcriptase inhibitor that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• Didanosine (enteric-coated) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• didanosine + lamivudine + efavirenz · Clinical Trial Agency of HIV Study Group · Antiretroviral combination therapy (NRTI + NNRTI) · Infectious Disease / Virology
  This combination of three antiretroviral drugs inhibits HIV replication by blocking reverse transcriptase and integrase enzymes required for viral reproduction.
• Tenofovir/Emtricitabine · Bristol-Myers Squibb · Nucleoside/nucleotide reverse transcriptase inhibitor (NRTI/NtRTI) combination · Infectious Disease / Virology
  Tenofovir and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Over-encapsulated efavirenz · University of Minnesota · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  Over-encapsulated efavirenz is a reformulation of the HIV reverse transcriptase inhibitor efavirenz designed to improve tolerability by reducing peak plasma concentrations and CNS exposure through modified-release encapsulation.

Phase 3 pipeline (38)

• Tenofovir/emtricitabine FDC · ViiV Healthcare · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease / Virology
  Tenofovir and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• stavudine extended-release, lamivudine, efavirenz · Bristol-Myers Squibb · NRTI and NNRTI combination · Infectious Disease
  Stavudine extended-release, lamivudine, and efavirenz work together to inhibit viral replication by targeting the HIV reverse transcriptase enzyme and the HIV non-nucleoside reverse transcriptase inhibitor binding site.
• daily TDF/FTC · National Institute of Allergy and Infectious Diseases (NIAID) · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease / Virology
  TDF/FTC is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors that block HIV reverse transcriptase to prevent viral replication.
• Doravirine/Lamivudine/Tenofovir · Thomas Jefferson University · Antiretroviral combination (NNRTI + NRTI + NtRTI) · Infectious Disease / Virology
  This fixed-dose combination inhibits HIV reverse transcriptase and integrase to block viral replication.
• Suraxavir Marboxil · Jiangxi Kvvit Pharmaceutical Co., Ltd. · Nucleotide reverse transcriptase inhibitor · Infectious diseases
  Suraxavir Marboxil is a prodrug of suraxavir, a nucleotide reverse transcriptase inhibitor.
• Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate · Merck Sharp & Dohme LLC · Antiretroviral combination (NNRTI + NRTIs) · Infectious Disease / Virology
  This combination drug inhibits HIV reverse transcriptase and integrase to block viral replication and reduce HIV viral load.
• Comparator: efavirenz · Merck Sharp & Dohme LLC · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Comparator: Placebo to efavirenz · Merck Sharp & Dohme LLC · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Comparator: Truvada · Merck Sharp & Dohme LLC · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  Truvada is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors (NRTIs) that blocks HIV reverse transcriptase to prevent viral replication.
• didanosine, ddI (drug) · French National Agency for Research on AIDS and Viral Hepatitis · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating within host cells.
• Placebo to FDC DOR/ISL · Merck Sharp & Dohme LLC · Antiretroviral combination (NNRTI + NRTI) · Infectious Disease / Virology
  A fixed-dose combination of doravirine and islatravir that inhibits HIV reverse transcriptase to suppress viral replication.
• Nevirapine, zidovudine, lamivudine · Institut de Recherche pour le Developpement · Antiretroviral combination therapy (NNRTI + NRTIs) · Infectious Disease / Virology
  This combination of three antiretroviral drugs inhibits HIV reverse transcriptase and non-nucleoside reverse transcriptase to suppress viral replication.
• Efavirenz + 2 NRTIs · National Institute of Allergy and Infectious Diseases (NIAID) · Antiretroviral combination therapy (NNRTI + 2 NRTIs) · Infectious Disease / Virology
  Efavirenz inhibits HIV reverse transcriptase while the two NRTIs (nucleoside reverse transcriptase inhibitors) act as chain terminators to block viral replication.
• Emtricitabine (FTC) · National University Hospital, Singapore · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing viral RNA from being converted into DNA and integrated into host cells.
• Oral RPV · National Institute of Allergy and Infectious Diseases (NIAID) · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease
  Oral RPV (rilpivirine) is a non-nucleoside reverse transcriptase inhibitor that blocks HIV reverse transcriptase to prevent viral replication.
• MK-8591A · Merck Sharp & Dohme LLC · Nucleoside reverse transcriptase translocation inhibitor (NRTI) · Infectious Disease / Virology
  MK-8591A is a nucleoside reverse transcriptase translocation inhibitor (NRTI) that blocks HIV reverse transcriptase by preventing the translocation of the enzyme along the viral RNA template.
• NVP+AZT · Johns Hopkins Bloomberg School of Public Health · Antiretroviral combination therapy (NNRTI + NRTI) · Infectious Disease / Virology
  NVP+AZT is a combination antiretroviral therapy that inhibits HIV reverse transcriptase through two nucleoside reverse transcriptase inhibitors (NRTIs), preventing viral replication.
• Rilpivirine Injectable Suspension · ViiV Healthcare · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• stavudine, efavirenz, lamivudine · Bristol-Myers Squibb · Antiretroviral combination therapy (NRTI/NNRTI) · Infectious Disease / Virology
  This is a fixed-dose combination of three nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV replication by inhibiting reverse transcriptase.
• emtricitabine, FTC (drug) · French National Agency for Research on AIDS and Viral Hepatitis · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• Nevirapine (NVP) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• Two NRTIs · ViiV Healthcare · Nucleoside reverse transcriptase inhibitor (NRTI) combination · Infectious Disease / Virology
  Two nucleoside reverse transcriptase inhibitors (NRTIs) work together to block HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and integrating into host cells.
• Lamivudine (3TC) · ViiV Healthcare · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks HIV reverse transcriptase, preventing viral RNA from being converted into DNA and integrated into host cells.
• FTC/TDF FDC · Janssen Sciences Ireland UC · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease
  FTC/TDF is a fixed-dose combination of two nucleoside reverse transcriptase inhibitors that block HIV reverse transcriptase to prevent viral replication.
• 2',3'-dideoxyinosine · National Cancer Institute (NCI) · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  2',3'-dideoxyinosine (ddI) is a nucleoside reverse transcriptase inhibitor that blocks HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Infant nevirapine · Centers for Disease Control and Prevention · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication in infants.
• TAF based regimen (TBR) · ViiV Healthcare · Nucleotide reverse transcriptase inhibitor (NtRTI) · Infectious Disease / Virology
  TAF (tenofovir alafenamide) is a nucleotide reverse transcriptase inhibitor that blocks HIV reverse transcriptase to prevent viral replication.
• NVP and AZT · Johns Hopkins Bloomberg School of Public Health · Antiretroviral combination therapy (NNRTI + NRTI) · Infectious Disease / Virology
  NVP and AZT are nucleoside reverse transcriptase inhibitors (NRTIs) that block HIV reverse transcriptase to prevent viral replication.
• Didanosine, Lamivudine, Nevirapine · Tuberculosis Research Centre, India · Antiretroviral combination (NRTI + NNRTI) · Infectious Disease / Virology
  This is a fixed-dose combination of three nucleoside/non-nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.
• Videx EC · Bristol-Myers Squibb · Nucleoside reverse transcriptase inhibitor (NRTI) · Infectious Disease / Virology
  Videx EC is a nucleoside reverse transcriptase inhibitor that blocks HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating.
• EFV plus ABC/3TC or RPV/TDF/FTC · Juan A. Arnaiz · Antiretroviral combination therapy (NNRTI + NRTIs) · Infectious Disease / Virology
  This is a combination antiretroviral regimen that inhibits HIV reverse transcriptase and integrase to suppress viral replication.
• Efavirenz QD + Zidovudine/Lamivudine BID · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Antiretroviral combination therapy (NNRTI + 2 NRTIs) · Infectious Disease / Virology
  This combination uses efavirenz (a non-nucleoside reverse transcriptase inhibitor) plus zidovudine and lamivudine (nucleoside reverse transcriptase inhibitors) to suppress HIV replication by blocking reverse transcriptase at multiple points.
• Efavirenz + Zidovudine/Lamivudine · ViiV Healthcare · Antiretroviral combination therapy (NNRTI + 2 NRTIs) · Infectious Disease / Virology
  This combination uses a non-nucleoside reverse transcriptase inhibitor (efavirenz) plus two nucleoside reverse transcriptase inhibitors (zidovudine and lamivudine) to block HIV replication at multiple steps.
• Efavirenz plus Lamivudine/Zidovudine · University of Cologne · Antiretroviral combination therapy (NNRTI + NRTIs) · Infectious Disease / Virology
  This combination inhibits HIV reverse transcriptase through three complementary mechanisms: efavirenz as a non-nucleoside reverse transcriptase inhibitor and lamivudine/zidovudine as nucleoside reverse transcriptase inhibitors.
• EFV/TDF/FTC · Juan A. Arnaiz · Antiretroviral combination therapy (NNRTI + NtRTI + NRTI) · Infectious Disease / Virology
  This is a fixed-dose combination of three antiretroviral agents that work together to inhibit HIV replication through different mechanisms: efavirenz blocks reverse transcriptase, while tenofovir and emtricitabine are nucleotide/nucleoside reverse transcriptase inhibitors.
• Dapivirine Vaginal Ring-004 · International Partnership for Microbicides, Inc. · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  Dapivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV replication when released from a vaginal ring formulation.
• NVP · Johns Hopkins Bloomberg School of Public Health · Non-nucleoside reverse transcriptase inhibitor (NNRTI) · Infectious Disease / Virology
  NVP is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV reverse transcriptase to prevent viral replication.
• Placebo to FTC/TDF · Merck Sharp & Dohme LLC · Nucleoside/nucleotide reverse transcriptase inhibitor combination · Infectious Disease
  FTC/TDF is a combination of two nucleoside reverse transcriptase inhibitors that block HIV replication by inhibiting the enzyme responsible for converting viral RNA into DNA.

Phase 2 pipeline (1)

• Anti-Retroviral Agents · Shanghai Public Health Clinical Center · Nucleoside Reverse Transcriptase Inhibitor · Infectious Disease
  Inhibits HIV reverse transcriptase