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Efavirenz plus Lamivudine/Zidovudine
Efavirenz plus Lamivudine/Zidovudine is a Antiretroviral combination therapy (NNRTI + NRTIs) Small molecule drug developed by University of Cologne. It is currently in Phase 3 development for HIV-1 infection.
This combination inhibits HIV reverse transcriptase through three complementary mechanisms: efavirenz as a non-nucleoside reverse transcriptase inhibitor and lamivudine/zidovudine as nucleoside reverse transcriptase inhibitors.
This combination inhibits HIV reverse transcriptase through three complementary mechanisms: efavirenz as a non-nucleoside reverse transcriptase inhibitor and lamivudine/zidovudine as nucleoside reverse transcriptase inhibitors. Used for HIV-1 infection.
At a glance
| Generic name | Efavirenz plus Lamivudine/Zidovudine |
|---|---|
| Sponsor | University of Cologne |
| Drug class | Antiretroviral combination therapy (NNRTI + NRTIs) |
| Target | HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | Phase 3 |
Mechanism of action
Efavirenz binds directly to HIV reverse transcriptase and blocks its catalytic activity. Lamivudine and zidovudine are nucleoside analogs that get incorporated into the growing viral DNA chain, causing chain termination and preventing viral replication. Together, these agents target reverse transcriptase through different mechanisms to suppress HIV viral load.
Approved indications
- HIV-1 infection
Common side effects
- Dizziness and CNS effects (efavirenz)
- Rash
- Nausea
- Headache
- Lipodystrophy (zidovudine)
- Anemia (zidovudine)
- Peripheral neuropathy (lamivudine/zidovudine)
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (PHASE2, PHASE3)
- Research on the Psychological Status of Patients With HIV-1 Infection
- A Prospective Cohort of Children With HIV Infection
- Effects of Maraviroc vs. Efavirenz on CD4/CD8 Ratio (PHASE3)
- The Effect of Aspirin on HIV Disease Progression Among HIV- Infected Individuals Initiating Anti- Retroviral Therapy (PHASE2)
- Preventing Sexual Transmission of HIV With Anti-HIV Drugs (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Efavirenz plus Lamivudine/Zidovudine CI brief — competitive landscape report
- Efavirenz plus Lamivudine/Zidovudine updates RSS · CI watch RSS
- University of Cologne portfolio CI
Frequently asked questions about Efavirenz plus Lamivudine/Zidovudine
What is Efavirenz plus Lamivudine/Zidovudine?
How does Efavirenz plus Lamivudine/Zidovudine work?
What is Efavirenz plus Lamivudine/Zidovudine used for?
Who makes Efavirenz plus Lamivudine/Zidovudine?
What drug class is Efavirenz plus Lamivudine/Zidovudine in?
What development phase is Efavirenz plus Lamivudine/Zidovudine in?
What are the side effects of Efavirenz plus Lamivudine/Zidovudine?
What does Efavirenz plus Lamivudine/Zidovudine target?
Related
- Drug class: All Antiretroviral combination therapy (NNRTI + NRTIs) drugs
- Target: All drugs targeting HIV reverse transcriptase
- Manufacturer: University of Cologne — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection
- Compare: Efavirenz plus Lamivudine/Zidovudine vs similar drugs
- Pricing: Efavirenz plus Lamivudine/Zidovudine cost, discount & access