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stavudine, efavirenz, lamivudine
stavudine, efavirenz, lamivudine is a Antiretroviral combination therapy (NRTI/NNRTI) Small molecule drug developed by Bristol-Myers Squibb. It is currently in Phase 3 development for HIV-1 infection.
This is a fixed-dose combination of three nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV replication by inhibiting reverse transcriptase.
This is a fixed-dose combination of three nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) and a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV replication by inhibiting reverse transcriptase. Used for HIV-1 infection.
At a glance
| Generic name | stavudine, efavirenz, lamivudine |
|---|---|
| Sponsor | Bristol-Myers Squibb |
| Drug class | Antiretroviral combination therapy (NRTI/NNRTI) |
| Target | HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | Phase 3 |
Mechanism of action
Stavudine and lamivudine are NRTIs that compete with natural nucleotides and cause chain termination during HIV reverse transcription. Efavirenz is an NNRTI that directly binds to and inhibits reverse transcriptase. Together, these three agents provide complementary inhibition of the enzyme essential for HIV replication, reducing viral load and slowing disease progression.
Approved indications
- HIV-1 infection
Common side effects
- Peripheral neuropathy
- Lipodystrophy
- Dizziness/CNS effects
- Rash
- Hepatotoxicity
- Pancreatitis
- Lactic acidosis
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- A Prospective Cohort of Children With HIV Infection
- Preventing Sexual Transmission of HIV With Anti-HIV Drugs (PHASE3)
- Anti-HIV Drug Regimens and Treatment-Switching Guidelines in HIV Infected Children (PHASE2, PHASE3)
- The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined With Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs (PHASE2)
- Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients (PHASE3)
- Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination With Nucleoside Analogs: A Rollover Study for ACTG 320 (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- stavudine, efavirenz, lamivudine CI brief — competitive landscape report
- stavudine, efavirenz, lamivudine updates RSS · CI watch RSS
- Bristol-Myers Squibb portfolio CI
Frequently asked questions about stavudine, efavirenz, lamivudine
What is stavudine, efavirenz, lamivudine?
How does stavudine, efavirenz, lamivudine work?
What is stavudine, efavirenz, lamivudine used for?
Who makes stavudine, efavirenz, lamivudine?
What drug class is stavudine, efavirenz, lamivudine in?
What development phase is stavudine, efavirenz, lamivudine in?
What are the side effects of stavudine, efavirenz, lamivudine?
What does stavudine, efavirenz, lamivudine target?
Related
- Drug class: All Antiretroviral combination therapy (NRTI/NNRTI) drugs
- Target: All drugs targeting HIV reverse transcriptase
- Manufacturer: Bristol-Myers Squibb — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection
- Compare: stavudine, efavirenz, lamivudine vs similar drugs
- Pricing: stavudine, efavirenz, lamivudine cost, discount & access