A Phase III, Randomized, Open-Label Comparison of Lopinavir/Ritonavir Plus Efavirenz Versus Lopinavir/Ritonavir Plus 2 NRTIs Versus Efavirenz Plus 2 NRTIs as Initial Therapy for HIV-1 Infection

NCT00050895 Phase 3 COMPLETED

With new strategies and drugs available, many different regimens exist for the treatment of HIV. The purpose of this study is to compare three different anti-HIV drug regimens as first-time treatments for HIV infection.

Details

Lead sponsor	National Institute of Allergy and Infectious Diseases (NIAID)
Phase	Phase 3
Status	COMPLETED
Enrolment	775
Completion	2006-03

Conditions

• HIV Infections

Interventions

• Lopinavir/ritonavir
• Efavirenz
• Stavudine
• Zidovudine
• Lamivudine
• Tenofovir disoproxil fumarate

Primary outcomes

• Time from study entry to virologic failure
• time from study entry to regimen completion

Countries

United States, South Africa