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Abacavir sulfate, Lamivudine and Zidovudine
Abacavir sulfate, Lamivudine and Zidovudine is a Nucleoside reverse transcriptase inhibitor (NRTI) combination Small molecule drug developed by National Institute of Allergy and Infectious Diseases (NIAID). It is currently FDA-approved for HIV-1 infection.
This combination of three nucleoside reverse transcriptase inhibitors (NRTIs) blocks HIV reverse transcriptase to prevent viral replication.
This combination of three nucleoside reverse transcriptase inhibitors (NRTIs) blocks HIV reverse transcriptase to prevent viral replication. Used for HIV-1 infection.
At a glance
| Generic name | Abacavir sulfate, Lamivudine and Zidovudine |
|---|---|
| Sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Drug class | Nucleoside reverse transcriptase inhibitor (NRTI) combination |
| Target | HIV reverse transcriptase |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Virology |
| Phase | FDA-approved |
Mechanism of action
Abacavir, lamivudine, and zidovudine are all NRTIs that inhibit HIV reverse transcriptase by competing with natural nucleosides and causing chain termination during viral DNA synthesis. When used together, they provide synergistic suppression of HIV replication and reduce the likelihood of resistance development. This triple-NRTI regimen was historically used as a backbone for antiretroviral therapy before the advent of more potent combination regimens.
Approved indications
- HIV-1 infection
Common side effects
- Hypersensitivity reaction (abacavir)
- Nausea
- Headache
- Diarrhea
- Fatigue
- Lactic acidosis (rare)
- Lipoatrophy
Key clinical trials
- Study of Cobicistat-Boosted Atazanavir (ATV/co), Cobicistat-Boosted Darunavir (DRV/co) and Emtricitabine/Tenofovir Alafenamide (F/TAF) in Children With HIV (PHASE2, PHASE3)
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments (PHASE4)
- Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With a Complicated Regimen (PHASE2, PHASE3)
- Reverse Transcriptase Inhibitors in AGS (PHASE2)
- Research on the Psychological Status of Patients With HIV-1 Infection
- A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed (PHASE2)
- A Study to Evaluate the Pharmacokinetics, Safety, Tolerability, and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years (PHASE2)
- Inhibition of Reverse Transcription in Aicardi-Goutières Syndrome (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Abacavir sulfate, Lamivudine and Zidovudine CI brief — competitive landscape report
- Abacavir sulfate, Lamivudine and Zidovudine updates RSS · CI watch RSS
- National Institute of Allergy and Infectious Diseases (NIAID) portfolio CI
Frequently asked questions about Abacavir sulfate, Lamivudine and Zidovudine
What is Abacavir sulfate, Lamivudine and Zidovudine?
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Who makes Abacavir sulfate, Lamivudine and Zidovudine?
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Related
- Drug class: All Nucleoside reverse transcriptase inhibitor (NRTI) combination drugs
- Target: All drugs targeting HIV reverse transcriptase
- Manufacturer: National Institute of Allergy and Infectious Diseases (NIAID) — full pipeline
- Therapeutic area: All drugs in Infectious Disease / Virology
- Indication: Drugs for HIV-1 infection
- Compare: Abacavir sulfate, Lamivudine and Zidovudine vs similar drugs
- Pricing: Abacavir sulfate, Lamivudine and Zidovudine cost, discount & access