H1-receptor — Drug Target
All drugs that target H1-receptor — marketed and clinical-stage. Includes 10 drug classes acting on this target.
Drug classes
H1-receptor antagonist · H1-receptor antagonist (second-generation antihistamine) · First-generation H1 receptor antagonist · Histamine-1 Receptor Antagonist [EPC] · Selective H1-receptor antagonist (antihistamine) · H1 receptor antagonist · Histamine H1 receptor antagonist · H1-receptor antagonist / mast cell stabilizer · H1-receptor antagonist (second-generation/non-sedating antihistamine) · Histamine H1-receptor antagonist
Marketed (17)
- olopatadine 0.2% ophthalmic solution · Allergan · H1-receptor antagonist · Ophthalmology
Olopatadine blocks H1-receptors on ocular mast cells and other immune cells to reduce histamine-mediated itching and allergic inflammation in the eye. - azelastine hydrochloride 0.05% · Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Azelastine hydrochloride is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in the nasal mucosa. - Diphenhydramine (Benadryl) · United States Army Institute of Surgical Research · First-generation H1 receptor antagonist · Allergy/Immunology
Diphenhydramine blocks histamine H1 receptors, preventing histamine-mediated allergic and inflammatory responses. - placebo to levocetirizine · Brian J Lipworth · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms. - Desloratadine and pseudoephedrine · Dr. Reddy's Laboratories Limited · Histamine-1 Receptor Antagonist [EPC]
Desloratadine blocks histamine H1 receptors, reducing allergy symptoms; pseudoephedrine relieves nasal congestion by constricting blood vessels. - levocetirizine (Xyzal) · AAADRS Clinical Research Center · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms. - Levocetirizine (drug) · UCB Pharma · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on mast cells and basophils, preventing allergic cascade activation. - Levocetirizine only · University Hospital, Grenoble · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms. - Cetirizine drops · UCB Pharma · H1-receptor antagonist (second-generation antihistamine) · Immunology / Allergy
Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on mast cells and basophils, preventing allergic cascade activation. - Levocetirizine oral solution · UCB Pharma · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. - DOXEPIN HYDROCHLORIDE
Doxepin may help maintain sleep by blocking H1 receptors. - Lastacaft ® · ORA, Inc. · Selective H1-receptor antagonist (antihistamine) · Ophthalmology / Allergy
Lastacaft is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses in the eye. - Zyrtec® (cetirizine) · Organon and Co · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, preventing allergic symptoms. - Cetirizine tablets · UCB Pharma · H1-receptor antagonist (second-generation antihistamine) · Immunology / Allergy
Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, reducing allergic symptoms. - Hidra1 · Farmoquimica S.A. · H1 receptor antagonist · Allergy
Hidra1 is an antihistamine that works by blocking the action of histamine in the body. - Cetirizine (Zyrtec) · Organon and Co · H1-receptor antagonist (second-generation antihistamine) · Immunology / Allergy
Cetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on cells, preventing allergic symptoms. - Xarlin (Levocetirizine) · HK inno.N Corporation · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine binding to H1 receptors on mast cells and basophils, reducing allergic symptoms.
Phase 3 pipeline (7)
- fexofenadine HCL (M016455) · Sanofi · Histamine H1 receptor antagonist · Allergy
Fexofenadine HCL is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergy symptoms. - Cetirizine Dry Syrup · GlaxoSmithKline · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. - H1 Receptor Antagonist · Merck Sharp & Dohme LLC · H1 receptor antagonist · Allergy/Immunology
H1 receptor antagonists block histamine binding to H1 receptors, reducing histamine-mediated allergic and inflammatory responses. - Olopatadine 0.1% Rescue Treatment · ALK-Abelló A/S · H1-receptor antagonist / mast cell stabilizer · Ophthalmology / Allergy
Olopatadine is a selective H1-receptor antagonist and mast cell stabilizer that blocks histamine-mediated allergic responses in the eye. - Placebo-Levocetirizine · UCB Pharma · H1-receptor antagonist (second-generation antihistamine) · Allergy/Immunology
Levocetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. - Desloratadine given orally · Hoffmann-La Roche · H1-receptor antagonist (second-generation/non-sedating antihistamine) · Allergy/Immunology
Desloratadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses without significant central nervous system penetration. - Olopatadine HCl NS · Glenmark Specialty S.A. · H1-receptor antagonist / mast cell stabilizer · Allergy / Immunology
Olopatadine HCl is a selective H1-receptor antagonist and mast cell stabilizer that reduces allergic inflammation in the nasal cavity.
Phase 2 pipeline (4)
- Epinastine Nasal Spray · Merck Sharp & Dohme LLC · Histamine H1-receptor antagonist · Respiratory
Epinastine is a selective histamine H1-receptor antagonist that blocks the action of histamine on nasal mucosa, reducing symptoms of allergic rhinitis. - Bilastine 0.6% · Faes Farma, S.A. · H1-receptor antagonist · Allergy
Bilastine is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergy symptoms. - H1 antihistamines · Genentech, Inc. · H1 receptor antagonist · Respiratory
Blocks H1 histamine receptors - Bilastine 0.4% · Faes Farma, S.A. · H1 receptor antagonist · Allergy
Bilastine is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergy symptoms.