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Epinastine Nasal Spray
Epinastine Nasal Spray is a Histamine H1-receptor antagonist Small molecule drug developed by Merck Sharp & Dohme LLC. It is currently in Phase 2 development for Allergic rhinitis.
Epinastine is a selective histamine H1-receptor antagonist that blocks the action of histamine on nasal mucosa, reducing symptoms of allergic rhinitis.
Epinastine is a selective histamine H1-receptor antagonist that blocks the action of histamine on nasal mucosa, reducing symptoms of allergic rhinitis. Used for Allergic rhinitis.
At a glance
| Generic name | Epinastine Nasal Spray |
|---|---|
| Sponsor | Merck Sharp & Dohme LLC |
| Drug class | Histamine H1-receptor antagonist |
| Target | H1-receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory |
| Phase | Phase 2 |
Mechanism of action
By antagonizing the H1-receptors, epinastine prevents the vasodilation and increased vascular permeability caused by histamine, which are key contributors to nasal congestion and other symptoms of allergic rhinitis.
Approved indications
- Allergic rhinitis
Common side effects
- Nasal discomfort
- Headache
Key clinical trials
- Safety and Efficacy Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis (P08648) (PHASE3)
- Two Formulations and Concentrations of Epinastine Nasal Spray Versus Azelastine Nasal Solution for Allergic Rhinitis (PHASE2)
- A Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Epinastine Nasal Spray CI brief — competitive landscape report
- Epinastine Nasal Spray updates RSS · CI watch RSS
- Merck Sharp & Dohme LLC portfolio CI
Frequently asked questions about Epinastine Nasal Spray
What is Epinastine Nasal Spray?
How does Epinastine Nasal Spray work?
What is Epinastine Nasal Spray used for?
Who makes Epinastine Nasal Spray?
What drug class is Epinastine Nasal Spray in?
What development phase is Epinastine Nasal Spray in?
What are the side effects of Epinastine Nasal Spray?
What does Epinastine Nasal Spray target?
Related
- Drug class: All Histamine H1-receptor antagonist drugs
- Target: All drugs targeting H1-receptor
- Manufacturer: Merck Sharp & Dohme LLC — full pipeline
- Therapeutic area: All drugs in Respiratory
- Indication: Drugs for Allergic rhinitis
- Compare: Epinastine Nasal Spray vs similar drugs
- Pricing: Epinastine Nasal Spray cost, discount & access