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Cetirizine Dry Syrup
Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses.
Cetirizine is a selective H1-receptor antagonist that blocks histamine-mediated allergic responses. Used for Allergic rhinitis, Chronic urticaria, Allergic conjunctivitis.
At a glance
| Generic name | Cetirizine Dry Syrup |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | H1-receptor antagonist (second-generation antihistamine) |
| Target | H1-receptor |
| Modality | Small molecule |
| Therapeutic area | Allergy/Immunology |
| Phase | Phase 3 |
Mechanism of action
Cetirizine competitively binds to peripheral H1-receptors on mast cells and basophils, preventing histamine from triggering allergic cascade reactions. This reduces symptoms of allergies including itching, urticaria, and rhinitis. As a second-generation antihistamine, it has minimal central nervous system penetration due to its hydrophilic nature and low blood-brain barrier crossing.
Approved indications
- Allergic rhinitis
- Chronic urticaria
- Allergic conjunctivitis
Common side effects
- Headache
- Somnolence
- Pharyngitis
- Dry mouth
Key clinical trials
- Cetirizine Placebo Controlled Study For Perennial Allergic Rhinitis (PHASE3)
- Pharmacokinetic Study of Levocetirizine Oral Solution (PHASE1)
- Perennial Allergic Rhinitis In Pediatric Subjects (PHASE3)
- Study Of Cutaneous Disease Accompanied With Pruritus In Pediatrics (PHASE3)
- Study Of Atopic Dermatitis In Pediatrics (PHASE3)
- Study Of Perennial Allergic Rhinitis In Pediatrics (PHASE3)
- Efficacy and Safety of Cetirizine Tablets Versus Ketotifen Dry Syrup in Children With Perennial Allergic Rhinitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cetirizine Dry Syrup CI brief — competitive landscape report
- Cetirizine Dry Syrup updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI